Olmutinib (HM61713) reversed multidrug resistance by inhibiting the activity of ATP-binding cassette subfamily G member 2 in vitro and in vivo

Olmutinib could bind to ATP-binding cassette transporter subfamily G member 2 (ABCG2) ATP binding site, inhibit its drug efflux function, increase intracellular chemotherapeutic drug accumulation, and then restore sensitivity of multidrug resistance cells to ABCG2 substrate drug.298