کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8513073 | 1556490 | 2012 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Factors Influencing the Retention of Organic Solvents in Products Freeze-Dried From Co-Solvent Systems
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Factors Influencing the Retention of Organic Solvents in Products Freeze-Dried From Co-Solvent Systems Factors Influencing the Retention of Organic Solvents in Products Freeze-Dried From Co-Solvent Systems](/preview/png/8513073.png)
چکیده انگلیسی
Controlling residual solvent levels is a major concern in pharmaceutical freeze-drying from co-solvent systems. This review provides an overview of the factors influencing this process and estimates their potential to reduce residual solvents in freeze-dried products. Decreased solvent contents are potentially correlated with the lower solid content, complete excipient crystallization, higher water solubility, and smaller molecular sizes of the solvent. Although no general rule can be derived for the selection of appropriate freezing conditions, the freezing stage appears to play a major role in subsequent volatile retention. In contrast, diverse secondary drying conditions do not appear to impact the amount of solvent retained in lyophilisates, and modification of this stage is thus not assumed to be expedient. Co-solvents are strongly entrapped in an amorphous product matrix as soon as the local moisture content decreases below a certain level. Thus, the moisture content in the dried product layer adjacent to the sublimation interface might be a key factor. Therefore, extension of the high moisture content period during the primary drying phase as well as a postlyophilization humidification of the dried products are presumably promising approaches to promote solvent release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 8, August 2018, Pages 2005-2012
Journal: Journal of Pharmaceutical Sciences - Volume 107, Issue 8, August 2018, Pages 2005-2012
نویسندگان
Claudia Kunz, Henning Gieseler,