کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
8519497 1556889 2017 5 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Glycolytic enzyme inhibitory and antiglycation potential of rutin
ترجمه فارسی عنوان
پتانسیل مهارکننده آنزیم گلیکولیتیک و ضد انعقادی روتین
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موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
چکیده انگلیسی
The aim of the present was to determine the mechanism for the antidiabetic potential exerted by rutin by studying its effect on the glycolytic enzyme inhibitory and antiglycation potential. For the determination of glycolytic enzyme inhibitory potential of rutin, porcine pancreatic amylase inhibitory assay and α-glucosidase inhibitory assay were performed. The antiglycation potential was determined by glycation of bovine serum albumin followed by antiglycation estimation of fructosamines adducts, protein carbonyls, protein thiols, congo red absorbance. Rutin showed a significant inhibition of α-amylase (p < 0.001; 53.66%) and α-glucosidase (p < 0.001; 52.56%). To study antiglycation potential, various parameters were determined and fructosamine inhibition was found to be 35.55%, protein carbonyls were inhibited up to 13.49%. Protein thiols were inhibited up to 80.27%. In the present study, it was concluded that rutin showed glycolytic enzyme inhibitory and antiglycation potential.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Future Journal of Pharmaceutical Sciences - Volume 3, Issue 2, December 2017, Pages 158-162
نویسندگان
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