کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8531088 | 1559729 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of ginsenoside Rg1 against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice through inhibiting toll-like receptor 4 signaling pathway
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کلمات کلیدی
IL-6Hemeoxygenase-1MD2GCLMGCLCIRF3CD14IL-1βiNOSHO-1GSHMAPK - MAPKAST - آسپارتات ترانس آمینازAcute liver injury - آسیب حاد کبدAli - اماinterleukin 1β - اینترلوکین 1βinterleukin 6 - اینترلوکین 6aspartate transaminase - ترانس آمیناز آسپارتاتcluster of differentiation 14 - خوشه تمایز 14inducible nitric oxide synthase - سنتاز اکسید نیتریک القاییInterferon regulatory factor 3 - عامل تنظیمی اینترفرون 3reduced glutathione - کاهش گلوتاتیونglutamate-cysteine ligase modifier subunit - کلرید کلسیم کلسترول کلسیمglutamate-cysteine ligase catalytic subunit - کلوتامین کاتالیزوری لیگاز گلوتامات-سیستئینmitogen-activated protein kinases - کیناز پروتئین فعال Mitogen
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Acute liver injury (ALI) is a dramatic liver disease characterized by large areas of inflammation in the liver. This study aimed to investigate the protective effects of ginsenoside Rg1 (Rg1), a biologically active component in Panax ginseng, on lipopolysaccharide/d-galactosamine (LPS/D-GalN)-induced ALI in mice, and meanwhile explore the molecular mechanism in vivo and in vitro. Mice were pretreated with Rg1 for three days prior to LPS (40â¯Î¼g/kg)/D-GalN (700â¯mg/kg) administration. The results showed that Rg1 improved the survival rate and reduced the liver to body weight ratios in mice. Rg1 also reduced the production of oxidative markers such as MDA and MPO induced by LPS/D-GalN. In addition, Rg1 significantly decreased the production of inflammatory cytokines including TNF-α, IL-6, IL-1β, Mip-2, Mcp-1, iNOS, and increased the activity of anti-inflammatory cytokine IL-10. Moreover, Rg1 inhibited the protein expression of TLR4 and its downstream genes including NF-κB and MAPKs, which are involved in inflammatory response. Rg1 dramatically reduced oxidative stress by regulating the expression of efflux transporters Mrp2 and various enzymes including GCLC, GCLM, HO-1 and NQO1. However, the changes in these genes and protein induced by Rg1 were abrogated by TLR4 antagonist TAK-242 in vitro. In conclusion, Rg1 had hepatoprotective effect on LPS/D-GalN-induced ALI in mice. The protection may be associated with the inhibition of TLR4. These findings suggest that Rg1 may be a promising agent for prevention against ALI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 61, August 2018, Pages 266-276
Journal: International Immunopharmacology - Volume 61, August 2018, Pages 266-276
نویسندگان
Chenqing Ning, Xiaoguang Gao, Changyuan Wang, Xiaokui Huo, Zhihao Liu, Huijun Sun, Xiaobo Yang, Pengyuan Sun, Xiaodong Ma, Qiang Meng, Kexin Liu,