کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536785 | 1560917 | 2018 | 17 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Canine sarcomas as a surrogate for the human disease
ترجمه فارسی عنوان
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کلمات کلیدی
PNSTMYXmyxosarcomaSynovial cell sarcomaPWTFSARMSLIPSCsHSASTSOsteosarcoma - استئوسارکوماComparative oncology - انکولوژی تطبیقیCSA - ایالات مؤتلفهٔ آمریکاIHC - ایمونوهیستوشیمیImmunohistochemistry - ایمونوهیستوشیمیOsa - بخشDrug development - توسعه داروییgastrointestinal stromal tumors - تومورهای استرومای گوارشیPeripheral nerve sheath tumors - تومورهای غلاف عصبی محیطیGastrointestinal tract - دستگاه گوارشRhabdomyosarcoma - رابدومیوسارکوماSoft tissue sarcoma - سارکوم بافت نرمHistiocytic sarcoma - سارکوم هیستوسیتیکSarcomas - سارکوماCanine - سگFibrosarcoma - فیبراسارکومlymphangiosarcoma - لنفانژیارکومLeiomyosarcoma - لیومیوسارکوماLiposarcoma - لیپوسارکومGist - مشتاقgenome wide association studies - مطالعات ارتباط گسترده ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومHemangiosarcoma - همگانیسارکوم
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
چکیده انگلیسی
Pet dogs are becoming increasingly recognized as a population with the potential to inform medical research through their treatment for a variety of maladies by veterinary health professionals. This is the basis of the One Health initiative, supporting the idea of collaboration between human and animal health researchers and clinicians to study spontaneous disease processes and treatment in animals to inform human health. Cancer is a major health burden in pet dogs, accounting for approximately 30% of deaths across breeds. As such, pet dogs with cancer are becoming increasingly recognized as a resource for studying the pharmacology and therapeutic potential of anticancer drugs and therapies under development. This was recently highlighted by a National Academy of Medicine Workshop on Comparative Oncology that took place in mid-2015 (http://www.nap.edu/21830). One component of cancer burden in dogs is their significantly higher incidence of sarcomas as compared to humans. This increased incidence led to canine osteosarcoma being an important component in the development of surgical approaches for osteosarcoma in children. Included in this review of sarcomas in dogs is a description of the incidence, pathology, molecular characteristics and previous translational therapeutic studies associated with these tumors. An understanding of the patho-physiological and molecular characteristics of these naturally occurring canine sarcomas holds great promise for effective incorporation into drug development schemas, for evaluation of target modulation or other pharmacodynamic measures associated with therapeutic response. These data could serve to supplement other preclinical data and bolster clinical investigations in tumor types for which there is a paucity of human patients for clinical trials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 188, August 2018, Pages 80-96
Journal: Pharmacology & Therapeutics - Volume 188, August 2018, Pages 80-96
نویسندگان
Daniel L. Gustafson, Dawn L. Duval, Daniel P. Regan, Douglas H. Thamm,