کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8536868 | 1560921 | 2018 | 74 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Readers of DNA methylation, the MBD family as potential therapeutic targets
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
RTTTDGTETCpGNuRDMBDDnmtCIMPCGIIDHclonal hematopoiesis of indeterminate potentialMCPGDNA methyltransferase - DNA متیل ترانسفرازCpG island methylator phenotype - phenotype methylparate جزیره CpGIsocitrate dehydrogenase - ایزوسیترات دهیدروژنازNucleosome Remodeling and Deacetylase - بازسازی نولوزوم و دی اتیلازGene regulation - تنظیم ژنCpG island - جزیره CpGRett syndrome - سندروم رتDNA methylation - متیلاسیون DNACHiP - چیپChromatin - کروماتین
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
DNA methylation represents a fundamental epigenetic modification that regulates chromatin architecture and gene transcription. Many diseases, including cancer, show aberrant methylation patterns that contribute to the disease phenotype. DNA methylation inhibitors have been used to block methylation dependent gene silencing to treat hematopoietic neoplasms and to restore expression of developmentally silenced genes. However, these inhibitors disrupt methylation globally and show significant off-target toxicities. As an alternative approach, we have been studying readers of DNA methylation, the 5-methylcytosine binding domain family of proteins, as potential therapeutic targets to restore expression of aberrantly and developmentally methylated and silenced genes. In this review, we discuss the role of DNA methylation in gene regulation and cancer development, the structure and function of the 5-methylcytosine binding domain family of proteins, and the possibility of targeting the complexes these proteins form to treat human disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 184, April 2018, Pages 98-111
Journal: Pharmacology & Therapeutics - Volume 184, April 2018, Pages 98-111
نویسندگان
Gordon D. Ginder, David C. Jr.,