کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8537209 | 1561008 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A schizophrenia-like behavioral trait in the SHR model: Applying confirmatory factor analysis as a new statistical tool
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Questionnaires that assess symptoms of schizophrenia patients undergo strict statistical validation, often using confirmatory factor analysis (CFA). CFA allows testing the existence of a trait that both collectively explains the symptoms and gathers the information in a single general index. In rodents, some behaviors are used to model psychiatric symptoms, but no single test or paradigm adequately captures the disorder's phenotype in toto. This work investigated the existence of a behavioral trait in the SHR strain underlying five behavioral tasks used in schizophrenia animal studies and altered in this strain: locomotor activity, rearing behavior, social interaction, prepulse inhibition of startle and contextual fear conditioning. The analysis was conducted on a sample of Wistar (nâ¯=â¯290) and Spontaneously Hypertensive Rats (SHRs, nâ¯=â¯290). CFA showed the existence of a continuous trait in both strains, and higher values among SHRs. This work is the first to demonstrate the existence of a schizophrenia-like trait in an animal model. We suggest that using CFA to evaluate behavioral parameters in animals might facilitate the pre-clinical investigation of psychiatric disorders, diminishing the gap between animal and human studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 85, 13 July 2018, Pages 16-22
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 85, 13 July 2018, Pages 16-22
نویسندگان
Fernanda Fiel Peres, Raà Álvares Eufrásio, Douglas Albuquerque Gouvêa, Mariana Cepollaro Diana, Camila MaurÃcio Santos, Walter Swardfager, Vanessa Costhek AbÃlio, Hugo Cogo-Moreira,