Nitroxide Tempol down-regulates kinase activities associated with NADPH oxidase function in phagocytic cells and potentially decreases their fungicidal response

description. Up-stream modulation of NADPH oxidase: Kinases acting up-stream of NOX2 activity in the molecular pathway leading to the ROS generation and antifungal capability of neutrophils. Tempol can down-regulate the kinases activities and impair ROS-mediated fungicidal response.183