کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8545449 | 1561564 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroprotection and reduced gliosis by pre- and post-treatments of hydroquinone in a gerbil model of transient cerebral ischemia
ترجمه فارسی عنوان
محافظت از عصب و کاهش گلیوز توسط پیش و پس از درمان هیدروکینون در یک مدل خونریزی ایسکمی مغزی گذرا
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Hydroquinone (HQ), a major metabolite of benzene, exists in many plant-derived food and products. Although many studies have addressed biological properties of HQ including the regulation of immune responses and antioxidant activity, neuroprotective effects of HQ following ischemic insults have not yet been considered. Therefore, in this study, we examined neuroprotective effects of HQ against ischemic damage in the gerbil hippocampal cornu ammonis 1 (CA1) region following 5Â min of transient cerebral ischemia. We found that pre- and post-treatments with 50 and 100Â mg/kg of HQ protected CA1 pyramidal neurons from ischemic insult. Especially, pre- and post-treatments with 100Â mg/kg of HQ showed strong neuroprotective effects against ischemic damage. In addition, pre- and post-treatments with 100Â mg/kg of HQ significantly attenuated activations of astrocytes and microglia in the ischemic CA1 region compared to the vehicle-treated-ischemia-operated group. Briefly, these results show that pre- and post-treatments with HQ can protect neurons from transient cerebral ischemia and strongly attenuate ischemia-induced glial activation in the hippocampal CA1 region, and indicate that HQ can be used for both prevention and therapy of ischemic injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 278, 25 December 2017, Pages 230-238
Journal: Chemico-Biological Interactions - Volume 278, 25 December 2017, Pages 230-238
نویسندگان
Joon Ha Park, Chan Woo Park, Ji Hyeon Ahn, Soo Young Choi, Myoung Cheol Shin, Jun Hwi Cho, Tae-Kyeong Lee, In Hye Kim, Jeong Hwi Cho, Jae-Chul Lee, Yang Hee Kim, Young-Myeong Kim, Jong-Dai Kim, Hyun-Jin Tae, Bich Na Shin, Eun Joo Bae, Bai Hui Chen,