کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8546910 | 1561726 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of flavonoids from Cyclocarya paliurus leaves against carbon tetrachloride-induced acute liver injury in mice
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کلمات کلیدی
ALTCyclocarya paliurus (Batal.) IljinskajaMDAT-AOCCCl4DADnuclear magnetic resonance - رزونانس مغناطیسی هستهایROS - ROSAST - آسپارتات ترانس آمینازAspartate aminotransferase - آسپارتات ترانس آمیناز یا AST Alanine aminotransferase - آلانین آمینوترانسفرازFourier-transform infrared spectroscopy - تبدیل فوریه طیف سنجی مادون قرمزdiode array detection - تشخیص آرایه دیودNMR - تشدید مغناطیسی هستهای Hepatoprotection - حفاظت از هپاتیتSOD - سدsuperoxide dismutases - سوکسوکس دیسموتازهاMass spectrometry - طیف سنجی جرمیFT-IR - طیف سنجی مادون قرمز تبدیل فوریهTotal antioxidant capacity - ظرفیت آنتی اکسیدانی کلFlavonoids - فلاونوئیدهاmalondialdehyde - مالون دی آلدهیدbody weight - وزن بدنCarbon tetrachloride - کربن تتراکلریدHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کاراCyclocarya paliurus - گل رشتی CyclocaryaReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Protective effect of flavonoids from Cyclocarya paliurus leaves against carbon tetrachloride-induced acute liver injury in mice Protective effect of flavonoids from Cyclocarya paliurus leaves against carbon tetrachloride-induced acute liver injury in mice](/preview/png/8546910.png)
چکیده انگلیسی
Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus), known locally as 'sweet tea tree', is commonly cultivated in China. Flavonoids from Cyclocarya paliurus (Batal.) Iljinskaja (FC) is reported to exhibit multiple biological effects, including anti-inflammatory, anti-oxidant and anti-diabetic activities. However, their influence on carbon tetrachloride (CCl4)-induced acute liver injury remains unclear. This study was designed to investigate the hepatoprotective effect of total flavonoids from C. paliurus leaves. Results revealed that flavonoids from C. paliurus significantly decreased CCl4-induced elevation of activities of aspartate transaminase (AST), alanine transaminase (ALT) and superoxide dismutase (SOD) as well as the level of malondialdehyde (MDA), and markedly increased the levels of SOD, total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) compared with the model group. Structures of mainly compounds were elucidated by nuclear magnetic resonance (NMR), mass spectrometry (MS) spectroscopic and chemical analyses. This study clearly shows that flavonoids from C. paliurus exert a potent protective effect against CCl4-induced acute liver injury in mice. Its hepatoprotective effect appears to be closely associated with its antioxidant activity. The results indicated that flavonoids from C. paliurus leaves could be considered as a potent food supplement in the prevention of acute liver injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 119, September 2018, Pages 392-399
Journal: Food and Chemical Toxicology - Volume 119, September 2018, Pages 392-399
نویسندگان
Jianhua Xie, Wenjie Wang, Caijun Dong, Lixin Huang, Hui Wang, Chang Li, Shaoping Nie, Mingyong Xie,