کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8549859 | 1561868 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Childhood polybrominated diphenyl ether (PBDE) exposure and executive function in children in the HOME Study
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کلمات کلیدی
transthyretinCDCMCMCPCBsGSDTTRGAMFSIQPBDEsPolybrominated diphenyl ethers (PBDEs) - الیاف دیفنیل پلیبرومونید شده (PBDEs)geometric standard deviation - انحراف استاندارد هندسیstandard deviation - انحراف معیارgeneralized estimating equations - برآورد معادلات تعمیم یافتهPolychlorinated biphenyls - بیفنیل پلیکلر neurodevelopment - توسعه عصبیGEE - جیChildhood - دوران کودکیPolybrominated diphenyl ethers - دیفنیل اتر پلی بوروندیMarkov chain Monte Carlo - زنجیره مارکف مونت کارلوconfidence interval - فاصله اطمینانBehavior Rating Inventory of Executive Function - فهرست عملکرد رتبه بندی عملکرد اجراییBRIEF - مختصرGeneralized additive model - مدل افزایشی عمومیCenters for Disease Control and Prevention - مراکز کنترل و پیشگیری از بیماریCenter for the Health Assessment of Mothers and Children of Salinas - مرکز ارزیابی سلامت مادران و کودکان سالیناسFull Scale Intelligence Quotient - مقیاس کامل اطلاعات امتیازGeometric mean - میانگین هندسیodds ratio - نسبت شانس هاPostnatal - پس از زایمانexecutive function - کارکردهای اجرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
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چکیده انگلیسی
Prenatal exposure to polybrominated diphenyl ethers (PBDEs) have been reported to impair executive function in children, but little is known whether childhood PBDE exposures play a role. Using the Health Outcomes and Measures of the Environment (HOME) Study, a prospective birth cohort in the greater Cincinnati area, we investigated the association between repeated measures of PBDEs during childhood and executive function at 8 years in 208 children and whether effect modification by child sex was present. We used child serum collected at 1, 2, 3, 5, and 8 years to measure PBDEs. The Behavior Rating Inventory of Executive Function was completed by parents to assess executive function at 8 years. We used multiple informant models to examine childhood PBDEs during several exposure windows. Null associations were observed between early childhood PBDEs and executive function. However, we observed significant adverse associations between a 10-fold increase in concurrent concentrations of BDE-28 (β = 4.6, 95% CI 0.5, 8.7) and BDE-153 (β = 4.8, 95% CI 0.8, 8.8) with behavioral regulation. In addition, PBDEs at 8 years were significantly associated with poorer emotional and impulse control. No associations were noted between childhood PBDEs and metacognition or global executive function. However, child sex significantly modified the associations, with significantly poorer executive function among males with higher concurrent BDE-153, and null associations in females. Our study findings suggest that concurrent PBDE exposures during childhood may be associated with poorer executive function, specifically behavior regulation. Males may also be more sensitive to adverse associations of concurrent PBDEs on executive function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Hygiene and Environmental Health - Volume 221, Issue 1, January 2018, Pages 87-94
Journal: International Journal of Hygiene and Environmental Health - Volume 221, Issue 1, January 2018, Pages 87-94
نویسندگان
Ann M. Vuong, Kimberly Yolton, Kendra L. Poston, Changchun Xie, Glenys M. Webster, Andreas Sjödin, Joseph M. Braun, Kim N. Dietrich, Bruce P. Lanphear, Aimin Chen,