A 28-day subchronic feeding study of chicken injected by genetically modified DNA-vaccine of avian influenzas in Sprague-Dawley rats

The safety of Veterinary vaccines based on the meat vaccinated by modified highly pathogenic avian influenza (HPAI) vaccine after oral ingestion was evaluated. The assessment was conducted in Sprague-Dawley rats by a 28-days feeding study. We incorporated meat from vaccinated chicken and non-vaccinated chicken into rodent diets at two concentrations (7.5%, 15%) and administered to Sprague-Dawley rats (n = 10/sex/group) for 28 days. A commercialized rodent diet was fed to an additional group as control group. Body weight, feed consumption and toxicological response variables were measured, and gross as well as microscopic pathology were examined. No death or adverse effects were observed in the current feeding study. The results of most studies indicated that there were no adverse effects between the groups fed with diets containing fractions from meat of vaccinated animals and the groups consumed diets composed of edible fractions from meat of non-vaccination animals.