کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8550852 | 1562104 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A 28-day subchronic feeding study of chicken injected by genetically modified DNA-vaccine of avian influenzas in Sprague-Dawley rats
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کلمات کلیدی
OECDGMOsAvian influenza - آنفلوآنزای مرغیGenetically modified organisms - ارگانیسم های اصلاح شده ژنتیکیGenetically modified - اصلاح ژنتیکیstandard deviation - انحراف معیارFood safety - ایمنی غذاییOral ingestion - خوراک دهانیOrganization for Economic Cooperation and Development - سازمان همکاری های اقتصادی و توسعهhemagglutinin - هماگلوتینینVaccine - واکسن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The safety of Veterinary vaccines based on the meat vaccinated by modified highly pathogenic avian influenza (HPAI) vaccine after oral ingestion was evaluated. The assessment was conducted in Sprague-Dawley rats by a 28-days feeding study. We incorporated meat from vaccinated chicken and non-vaccinated chicken into rodent diets at two concentrations (7.5%, 15%) and administered to Sprague-Dawley rats (nâ¯=â¯10/sex/group) for 28 days. A commercialized rodent diet was fed to an additional group as control group. Body weight, feed consumption and toxicological response variables were measured, and gross as well as microscopic pathology were examined. No death or adverse effects were observed in the current feeding study. The results of most studies indicated that there were no adverse effects between the groups fed with diets containing fractions from meat of vaccinated animals and the groups consumed diets composed of edible fractions from meat of non-vaccination animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 98, October 2018, Pages 245-249
Journal: Regulatory Toxicology and Pharmacology - Volume 98, October 2018, Pages 245-249
نویسندگان
Yuan Cao, Xiaoyun He, Wentao Xu, Kunlun Huang,