کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551430 | 1562108 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interplay of gender, age and drug properties on reporting frequency of drug-induced liver injury
ترجمه فارسی عنوان
تعامل جنسیتی، سن و خواص دارویی در گزارش اغلب آسیب کبدی ناشی از مواد مخدر
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کلمات کلیدی
ALTEBGMFDABDDCSULNMedDRACmaxRRRCyPt1/2 - t1 / 2Adenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPDrug-induced liver injury - آسیب کبدی ناشی از مواد مخدرAlanine aminotransferase - آلانین آمینوترانسفرازALP - آلکالن فسفاتازAlkaline phosphatase - آلکالین فسفاتاز یا فسفاتاز قلیاییantinuclear antibody - آنتی بادی ضد سرطانیANA - اصلیGender differences - تفاوت های جنسیتیDILI - دیلیDILIN - زبانWorld Health Organization - سازمان بهداشت جهانیFood and Drug Administration - سازمان غذا و داروHepatocellular - سلول های بنیادیHepatotoxicity - سمیت کبدcytochrome - سیتوکرومDrug-Induced Liver Injury Network - شبکه های آسیب های کبدی ناشی از مواد مخدرconfidence interval - فاصله اطمینانodds ratio - نسبت شانس هاhalf life - نیمه عمرWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
We examined the effect of gender, age, and drug properties on liver events reporting frequency (RF) to assess patient- and drug-related risks for drug-induced liver injury (DILI). We performed a data-mining analysis of the WHO VigiBase⢠to 1) identify drugs with gender- and age-biased RF and 2) characterize drug properties using the Liver Toxicity Knowledge Base. Age-, gender-specific Empirical Bayes Geometric Mean of relative reporting ratio of liver events with 90% confidence interval (CI) was calculated for 375 drugs with DILI potential. Forty-one drugs showed an increased RF in women, which had a higher prevalence of reactive metabolite formation and mitochondrial dysfunction and transporter inhibition. Fifty-nine drugs showed an increased RF in younger women (<50â¯yrs), many of which had a signature pattern of hepatocellular injury. In contrast, half of 17 drugs that showed an increased RF in men had a cholestatic pattern. In the older group (â¥50â¯yrs), 17 drugs showed an increased RF and had higher transporter inhibition, Cmax, and plasma protein binding, yet shorter plasma elimination. Specific drug properties were associated with gender- and age-biased liver events RF, suggesting possible interactions of drug properties, gender, and age in DILI development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 94, April 2018, Pages 101-107
Journal: Regulatory Toxicology and Pharmacology - Volume 94, April 2018, Pages 101-107
نویسندگان
Nayana George, Minjun Chen, Nancy Yuen, Christine M. Hunt, Ayako Suzuki,