کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8551626 | 1562109 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of tobacco heating product THP1.0. Part 8: Study to determine puffing topography, mouth level exposure and consumption among Japanese users
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کلمات کلیدی
ADCPuffing topographyMLEBATTPMTHPHCIFDAPreclinical assessmentNicotine-free dry particulate matterNFDPMTHs - THSActual use - استفاده واقعیstandard deviation - انحراف معیارISO - ایزوHealth Canada Intense - بهداشت کانادا شدیدBritish American Tobacco - توتون و تنباکو انگلیسی آمریکاییTobacco heating product - توتون و تنباکو گرم محصولtotal particulate matter - ذرات جامدInternational Organization for Standardization - سازمان بین المللی استاندارد سازیFood and Drug Administration - سازمان غذا و داروTobacco heating system - سیستم گرمایش توتون و تنباکوmouth level exposure - قرار گرفتن در معرض سطح دهان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Assessment of tobacco heating product THP1.0. Part 8: Study to determine puffing topography, mouth level exposure and consumption among Japanese users Assessment of tobacco heating product THP1.0. Part 8: Study to determine puffing topography, mouth level exposure and consumption among Japanese users](/preview/png/8551626.png)
چکیده انگلیسی
A four-arm study was undertaken in Japan to determine the puffing topography, mouth level exposure and average daily consumption by consumers of the tobacco heating products (THPs): the non-mentholated THP1.0(T), the mentholated THP1.0(M) and a tobacco heating system (THS). The extent of lip blocking of air inlet holes while using THP1.0(T) was also assessed. Groups 1, 2, and 4 included smokers, and group 3 included regular THP users. Smokers of 7-8 mg ISO nicotine free dry particulate matter (NFDPM) non-mentholated cigarettes took on average larger mean puff volumes from THPs than from conventional cigarettes, but puff numbers and durations were similar. Mouth level exposure to NFDPM and nicotine levels were significantly lower when using THPs than conventional cigarettes. Similar trends were observed among smokers of 7-8 mg ISO NFDPM mentholated cigarettes who used mentholated cigarettes and THP1.0(M). Regular users of commercial THS had similar puffing behaviours irrespective of whether they were using THS or THP1.0(T), except for mean puff volume which was lower with THP1.0(T). No smokers blocked the air inlet holes when using THP1.0(T). The puffing topography results support the machine puffing regime used to generate toxicant emissions data and in vitro toxicology testing.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 93, March 2018, Pages 84-91
Journal: Regulatory Toxicology and Pharmacology - Volume 93, March 2018, Pages 84-91
نویسندگان
Jodie Gee, Krishna Prasad, Sandra Slayford, Adam Gray, Kathryn Nother, Anthony Cunningham, Eleni Mavropoulou, Christopher Proctor,