کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8634139 | 1569091 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Resveratrol supplementation decreases blood glucose without changing the circulating CD14+CD16+ monocytes and inflammatory cytokines in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study
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کلمات کلیدی
hsCRPNF-κBLDL-CHOMA-IRMCP-1SGOTSGPTFITCPBMCFBSHDL-CLPSTLRT2DHbA1cPBSPBMCshomeostasis model assessment of insulin resistance - ارزیابی مدل هومیوستاز مقاومت به انسولینinflammation - التهاب( توروم) interleukin - اینترلوکینtriacylglycerol - تری آسیل گلیسرول tumor necrosis factor α - تومور نکروز عامل αToll-like receptor - تیالآرWaist circumference - دور کمرType 2 diabetes - دیابت نوع 2Resveratrol - رسوراترولserum glutamate oxaloacetate transaminase - سرم گلوتامات اگزالا سیتات ترانس آمینازperipheral blood mononuclear cells - سلول های تک هسته ای خون محیطیbody mass index - شاخص توده بدنBMI - شاخص توده بدنیTNF-α - فاکتور نکروز توموری آلفاphycoerythrin - فایکوئیریدینfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتfasting blood glucose - قند خون ناشتاhigh-density lipoprotein cholesterol - لیپوپروتئین پرچگالی یا اچدیالlipopolysaccharide - لیپوپلی ساکاریدphosphate-buffered solution - محلول بافر فسفاتGlycated hemoglobin - هموگلوبین گلیکوزیلهmonocyte chemoattractant protein-1 - پروتئین شیمیایی monocyte chemoattractant-1high-sensitivity C-reactive protein - پروتئین واکنش پذیر با حساسیت بالا CClinical trial - کارآزمایی بالینیLow-density lipoprotein cholesterol - کلسترول لیپوپروتئین با چگالی کمserum glutamate pyruvate transaminase - گلوتامات سرم ترانس پیروات
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Resveratrol supplementation decreases blood glucose without changing the circulating CD14+CD16+ monocytes and inflammatory cytokines in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study Resveratrol supplementation decreases blood glucose without changing the circulating CD14+CD16+ monocytes and inflammatory cytokines in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled study](/preview/png/8634139.png)
چکیده انگلیسی
Chronic low-grade inflammation is the hallmark of type 2 diabetes (T2D). Although in vitro and animal studies have shown that resveratrol exerts anti-inflammatory effects, clinical trials addressing these effects in patients with T2D are limited. Therefore, in the present study, we hypothesized that supplementation of resveratrol might improve inflammatory markers in patients with T2D in a randomized, double-blind, placebo-controlled clinical trial. A total of 45 T2D patients were supplemented with either of 800â¯mg/d resveratrol or placebo capsules for 8 weeks. Percentage of CD14+CD16+ monocytes, plasma levels of inflammatory cytokines (tumor necrosis factor α, interleukin [IL] 1β, IL-6, and monocyte chemoattractant protein-1), the expression levels of genes involved in the inflammatory responses (toll-like receptor 2, toll-like receptor 4, and nuclear factor κB), lipopolysaccharide-stimulated cytokine (tumor necrosis factor α, IL-1β, and IL-6) secretion from peripheral blood mononuclear cells, and metabolic and anthropometric parameters were assessed at both the baseline level and the end of the study. Compared with the placebo group, we could not detect any significant difference in the percentage of CD14+CD16+ monocytes, lipopolysaccharide-induced cytokine secretion, plasma levels of inflammatory cytokines, and the expression of inflammatory genes in resveratrol group. Moreover, we did not find any significant change in the metabolic and anthropometric parameters except for a significant reduction in fasting blood glucose and blood pressure. In conclusion, 8-week supplementation of resveratrol reduces blood glucose level in patients with T2D without improving their inflammatory markers.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition Research - Volume 54, June 2018, Pages 40-51
Journal: Nutrition Research - Volume 54, June 2018, Pages 40-51
نویسندگان
Hadi Khodabandehloo, ShadiSadat Seyyedebrahimi, Ensieh Nasli Esfahani, Farideh Razi, Reza Meshkani,