کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8634871 | 1569135 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Allele distribution and testing for association between an oxygen dependent degradation domain SNP in EPAS1 and pulmonary arterial pressures in yearling Angus cattle
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کلمات کلیدی
mPAPN-terminal transactivation domainODDDN-TADRHFEPAS1HIFHWENTCAngus - انگوسanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceTris-EDTA - تریس-EDTAHardy-Weinberg equilibrium - تعادل هاردی-وینبرگoxygen-dependent degradation domain - دامنه تخریب وابسته به اکسیژنHypoxia-induced factor - عامل ناشی از هیپوکسیPulmonary arterial pressure - فشار شریان ریویmean pulmonary arterial pressure - فشار متوسط شریان ریویRight heart failure - نقص قلب راستpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازPulmonary hypertension - پرفشاری خون ریویSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدquality control - کنترل کیفیتCattle - گاو
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Allele distribution and testing for association between an oxygen dependent degradation domain SNP in EPAS1 and pulmonary arterial pressures in yearling Angus cattle Allele distribution and testing for association between an oxygen dependent degradation domain SNP in EPAS1 and pulmonary arterial pressures in yearling Angus cattle](/preview/png/8634871.png)
چکیده انگلیسی
At altitudes >1500â¯m, measurements of mean pulmonary arterial pressures (mPAP; mmHg) are a measure of pulmonary hypertension (PH) in cattle. Genotypes of a G/A single nucleotide polymorphism (SNP; rs208684340) in the endothelial PAS domain protein 1 (EPAS1) gene were determined for mPAP categories (low, moderate, high) on Angus cattle. The A allele of this SNP was postulated to be associated with altitude-induced PH. The first objective was to estimate allele and genotypic frequencies in Angus cattle at high- (elevation 1850 to 2800â¯m) and low-altitude (elevation 91 to 1192â¯m) ranches (nâ¯=â¯118; random sample of 1275). Percent of cattle at these low elevation ranches with genotypes G/G, G/A, and A/A were 64.4, 33.9, and 1.7%, respectively, and a minor allele frequency (MAF; A allele) of 18.6%. Bulls, steers, and heifers (nâ¯=â¯691) from 4 high-altitude Angus herds in Colorado and Wyoming were genotyped. Percent of cattle with genotypes G/G, G/A, and A/A were 48.6, 34.3, and 17.1%, respectively, with a MAF of 34.2%. Average mPAP was 40.5â¯Â±â¯8.8â¯mmHg. Low, moderate, and high-mPAP category MAF were similar (Ï2â¯=â¯3.03; Pâ¯=â¯0.22), with values of 35.4, 31.0, and 37.8%, respectively. Additionally we sought to evaluate the genotype-to-phenotype association of this SNP with mPAP phenotypes (nâ¯=â¯532) from the Colorado State University Beef Improvement Center (elevation 2150â¯m) Angus herd. Linear mixed model analysis suggested genotype was not a predictor (Pâ¯=â¯0.61) of mPAP. Results do not suggest the A allele of SNP in EPAS1 is associated with high altitude-induced PH in yearling Angus cattle.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Agri Gene - Volume 9, September 2018, Pages 27-31
Journal: Agri Gene - Volume 9, September 2018, Pages 27-31
نویسندگان
N.F. Crawford, S.J. Coleman, T.N. Holt, S.E. Speidel, R.M. Enns, R. Hamid, M.G. Thomas,