کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8646334 | 1570092 | 2018 | 44 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Whole genome DNA methylation profiling of oral cancer in ethnic population of Meghalaya, North East India reveals novel genes
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کلمات کلیدی
TSSCGIHNSCCDMPSSNPsFDROSCCDMRs - DMR هاEpigenetics - اپی ژنتیکIma - ایماWhole-genome - تمام ژنومKEGG یا Kyoto Encyclopedia of Genes and Genomes - دایرة المعارف ژن ها و ژنوم کیوتو Kyoto Encyclopedia of Genes and Genomes - دایره المعارف ژنتیک ژن ها و ژنوم کیوتوDAVID - دیویدtranscription start site - رونویسی شروع سایتOral cancer - سرطان دهانDNA methylation - متیلاسیون DNAUTR یا untranslated regions - منطقه ترجمه نشدهuntranslated region - منطقه غیر ترجمهfalse discovery rate - میزان کشف کاذبGene ontology - هستیشناسی ژنیdatabase for annotation, visualization and integrated discovery - پایگاه داده برای حاشیه نویسی، تجسم و کشف یکپارچهSingle nucleotide polymorphisms - پلیمورفیسم تک نوکلئوتیدیHead and neck squamous cell carcinoma - کارسینوم سلول سنگفرشی سر و گردن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oral Squamous Cell Carcinoma (OSCC) is a serious and one of the most common and highly aggressive malignancies. Epigenetic factors such as DNA methylation have been known to be implicated in a number of cancer etiologies. The main objective of this study was to investigate physiognomies of Promoter DNA methylation patterns associated with oral cancer epigenome with special reference to the ethnic population of Meghalaya, North East India. The present study identifies 27,205 CpG sites and 3811 regions that are differentially methylated in oral cancer when compared to matched normal. 45 genes were found to be differentially methylated within the promoter region, of which 38 were hypermethylated and 7 hypomethylated. 14 of the hypermethylated genes were found to be similar to that of the TCGA-HNSCC study some of which are TSGs and few novel genes which may serve as candidate methylation biomarkers for OSCC in this poorly characterized ethnic group.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 110, Issue 2, March 2018, Pages 112-123
Journal: Genomics - Volume 110, Issue 2, March 2018, Pages 112-123
نویسندگان
Shngainlang Khongsti, Frederick A. Lamare, Neizekhotuo Brian Shunyu, Sahana Ghosh, Arindam Maitra, Srimoyee Ghosh,