کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8715932 | 1587875 | 2018 | 34 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
LMO4 Is a Disease-Provocative Transcription Coregulator Activated by IL-23 in Psoriatic Keratinocytes
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کلمات کلیدی
STAT3KGMacutely transforming retrovirus AKT8 in rodent T-cell lymphomaIVLLMO4phosphorylated-AKTp-Akt - P-AKTAkt - آکتsignal transducer and activator of transcription 3 - مبدل سیگنال و فعال کننده رونویسی 3keratinocyte growth medium - محیط رشد کراتینوسیتkeratin 5 - کراتین 5Keratinocyte - کراتینوسیتinvolucrin - گیرنده
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Psoriasis is an autoimmune disease characterized by abnormal differentiation and hyperproliferation of epidermal keratinocytes. LIM-domain only protein 4 (LMO4) is a transcription factor coregulator that promotes the assembly of multiprotein complexes to regulate mammary epithelium and keratinocyte differentiation and proliferation during embryogenesis. In this study, LMO4 has been found to be abundantly expressed in psoriatic epidermis. LMO4 expression is increased in human keratinocytes induced to differentiate by calcium ex vivo, and LMO4 overexpression induces spontaneous differentiation and growth acceleration of human keratinocytes in the absence of calcium. IL-23, a cytokine highly expressed in psoriatic skin lesions, induces differentiation and promotes proliferation of human keratinocytes. The IL-23-mediated effects are accompanied by an increase in LMO4 expression mediated by signal transducer and activator of transcription 3 through an IL-23/acutely transforming retrovirus AKT8 in rodent T-cell lymphoma/signal transducer and activator of transcription 3 pathway in keratinocytes. Knockdown of LMO4 effectively inhibits differentiation and growth of keratinocytes both ex vivo and in IL-23-injected ears of mice. LMO4 appears to mediate IL-23-related responses in psoriatic keratinocytes and is a potential therapeutic target in psoriasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 5, May 2018, Pages 1078-1087
Journal: Journal of Investigative Dermatology - Volume 138, Issue 5, May 2018, Pages 1078-1087
نویسندگان
Zhenzhen Tu, Siping Zhang, Guoling Zhou, Lili Zhou, Qiantong Xiang, Qiongqiong Chen, Pan Zhao, Heqin Zhan, Haisheng Zhou, Liangdan Sun,