کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8723125 | 1589617 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in Bone Health During the First Year of Cancer Treatment in Children
ترجمه فارسی عنوان
تغییرات در سلامت استخوان در اولین سال درمان سرطان در کودکان
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
تراکم معدنی استخوان، درمان سرطان، فرزندان،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی
This study aimed to evaluate longitudinal changes in bone mineral density (BMD) and bone mineral content (BMC) in children with cancer during the first year of treatment. Thirty pediatric cancer patients (median age 11.2 [range 3.8-17.4]âyr; 21 boys, 9 girls; 19 hematologic malignancies, 11 solid tumors) and 30 healthy controls were enrolled. Dual energy X-ray absorptiometry was performed at baseline and at 1, 6, and 12âmo for each pediatric cancer patient. There were no significant differences in age, sex, body weight, height, body mass index, serum vitamin D levels, BMD, and BMC among children with hematologic malignancies, those with solid tumors, and the controls at baseline. When the medians of BMD Z-scores were compared between different time intervals, whole-body BMD Z-score significantly decreased during the first year of cancer treatment (pâ=â0.001) in children with hematologic malignancies, especially during the first month (pâ=â0.002), and between 1 and 6âmo (pâ=â0.006). In children with solid tumors, whole-body BMD Z-score changed significantly only between 6 and 12âmo after treatment (pâ=â0.043). Generalized estimation equations for the analysis of trends in the whole-body BMD Z-scores revealed that there were significant downward trends between BMD Z-scores at baseline and those at 12âmo in children with hematologic malignancies and those with solid tumors. Cancer treatment significantly affects the bone health status at least during the first year, causing a significant decrease in BMD, especially during the first 6âmo for patients with hematologic malignancies and during the last 6âmo for those with solid tumors. Better strategies for treating changes in BMD based on the underlying cancer are necessary during cancer treatment in children.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Densitometry - Volume 20, Issue 1, JanuaryâMarch 2017, Pages 25-31
Journal: Journal of Clinical Densitometry - Volume 20, Issue 1, JanuaryâMarch 2017, Pages 25-31
نویسندگان
Hyoung Soo Choi, Eun Jae Chang, Eun Hye Lee, Hye Ran Yang,