کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8738280 | 1591525 | 2018 | 18 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Vitamin D inhibits palmitate-induced macrophage pro-inflammatory cytokine production by targeting the MAPK pathway
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کلمات کلیدی
VDRLPSIL-6FFAsJnkTLR4FBSRT-qPCR1,25-(OH)2D3 - 1،25- (OH) 2D31,25-dihydroxyvitamin D3 - 1،25-دی هیدروکسوییتامین D3c-Jun N-terminal kinase - C-Jun N-terminal kinaseERK1/2 - ERK1 / 2MAPK - MAPKFree fatty acids - اسیدهای چرب آِزادsaturated fatty acids - اسیدهای چرب اشباع شدهinterleukin 6 - اینترلوکین 6tumor necrosis factor α - تومور نکروز عامل αreal-time quantitative PCR - زمان واقعی PCR کمیfetal bovine serum - سرم جنین گاوPro-inflammatory cytokines - سیتوکینهای پروتئین التهابیTNF-α - فاکتور نکروز توموری آلفاlipopolysaccharide - لیپوپلی ساکاریدToll like receptor 4 - مانند گیرنده 4Macrophage - ماکروفاژ MAPK signaling pathway - مسیر سیگنال MAPKVitamin D - ویتامین دیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenextracellular signal-regulated kinase 1/2 - کیناز 1/2 تنظیم سیگنال خارج سلولیVitamin D receptor - گیرنده ویتامین D
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Vitamin D insufficiency is associated with chronic inflammatory diseases. However, the mechanism by which vitamin D reduces obesity-related inflammation remains poorly understood. In this study, we investigated the inhibitory effects of vitamin D on palmitate-induced inflammatory response in macrophages and explored the potential mechanisms of vitamin D action. The effect of vitamin D on the expression of inflammatory factors induced by palmitate, a saturated fatty acid, was investigated using human THP-1 macrophages and murine RAW 264.7 cells. To elucidate the mechanism by which vitamin D affects palmitate-induced inflammatory cytokine production, we investigated the activity of stress kinase-related proteins. Palmitate significantly increased TNF-α and IL-6 expression and secretion in THP-1 and RAW 264.7 macrophages. Treatment with the active form of vitamin D inhibited palmitate-induced TNF-α and IL-6 production in macrophages. Furthermore, vitamin D significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2). The mitogen-activated protein kinase signaling pathway partly accounts for the induction of pro-inflammatory cytokines by palmitate. Our data suggest that the attenuation of palmitate-induced TNF-α and IL-6 gene expression and protein secretion by vitamin D are associated with reduced activation of JNK and ERK1/2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 202, October 2018, Pages 23-30
Journal: Immunology Letters - Volume 202, October 2018, Pages 23-30
نویسندگان
Wei Li, Zhuo Liu, Renqiao Tang, Shengrong Ouyang, Sen Li, Jianxin Wu,