کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8749305 | 1593667 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An in silico study: Novel targets for potential drug and vaccine design against drug resistant H. pylori
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کلمات کلیدی
H. pyloriCELLOLipopolysacharideSTRINGPGNMDRTTDCAILPSPSI-BLAST - PSI BLASTSimple modular architecture research tool - ابزار تحقیق معماری مدولار سادهTherapeutic targets - اهداف درمانیNetwork analysis - تجزیه و تحلیل شبکهCodon adaptation index - شاخص سازگاری کدونDEG - شماDruggability - عدم مصرف داروMetabolic pathways - مسیرهای متابولیکMultidrug resistant - مقاوم در برابر چند داروSMART - هوشمندانهDatabase of Essential Genes - پایگاه داده ژن های ضروریPeptidoglycan - پپتیدوگلیکان
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Gastric cancer risk and adverse ramifications by augmented multi-drug resistance (MDR) of Helicobacter pylori are alarming serious health concern. Combating through available drugs is a difficult task due to lack of appropriate common targets against genetically diverse strains. To improve efficacy, the effective targets should be identified and critically assessed. In the present study, we aim to predict the potential novel targets against H. pylori strains by employing computer aided approach. The genomic dataset of 53 H. pylori strains was comparatively processed and eventually predicted 826 'conserved gene products'. Further, we performed subtractive genomic approach in search of promising crucial targets through the combination of in silico analyses. Codon adaptation index (CAI) value calculation and literature surveys were also done in order to find highly expressed gene products with novelty. Consequently, four enzymes and three membrane proteins were prioritized as new therapeutic and vaccine targets respectively which found to have more interactors in network with high-confidence score, druggability, antigenicity and molecular weight <110â¯kDa. Therefore, our results underpin the importance of new targets may counteract with false-positive/negatives and facilitate appropriate potential targets for a new insight of reliable therapeutic development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbial Pathogenesis - Volume 122, September 2018, Pages 156-161
Journal: Microbial Pathogenesis - Volume 122, September 2018, Pages 156-161
نویسندگان
Chiranjeevi Pasala, Chandra Sekhar Reddy Chilamakuri, Sudheer Kumar Katari, Ravina Madhulitha Nalamolu, Aparna R. Bitla, Amineni Umamaheswari,