کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8814789 | 1608037 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development Variation of genes encoding KAT1, AADAT and IDO1 as a potential risk of depression development](/preview/png/8814789.png)
چکیده انگلیسی
Numerous data suggests that the disorders of tryptophan catabolites (TRYCATs) pathway, including a decreased level of tryptophan or evaluated concentration of harmful TRYCATs âkynurenine, quinolinic acid, 3-hydroxyanthranilic acid, 3-hydroxytryptophan â may cause the occurrence of DD symptoms. In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development. Our study was performed on the DNA isolated from peripheral blood of 281 depressed patients and 236 controls. We genotyped, by using TaqMan probes, four polymorphisms: c.*456G > A of KAT1 (rs10988134), c.975-7T > C of AADAT (rs1480544), c.-1849C > A (rs3824259) and c.-1493G > C(rs10089084)of IDO1. We found that only the A/A genotype of c.*456G > A â KAT1 (rs10988134) increased the risk of depression occurrence. Interestingly, when we stratified the study group according to gender, this relationship was present only in male population. However, a gene-gene analysis revealed a link between the T/T-C/C genotype of c.975-7T > C â AADAT (rs1480544)or c.-1493G > C â IDO1 (rs10089084) and C/C-C/A genotype of c.975-7T > C â AADAT (rs1480544)and c. â1849C > A â IDO1 (rs3824259) and the disease. Moreover, we found, that the c.975-7T > C â AADAT and c. *456G > A KAT1 (rs10988134) polymorphisms may modulate the effectiveness of selective serotonin reuptake inhibitors therapy. Concluding, our results confirm the hypothesis formulated in our recently published article that the SNPs of genes involved in TRYCATs pathway may modulate the risk of depression. This provides some further evidence that the pathway plays the crucial role in development of the disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Psychiatry - Volume 52, August 2018, Pages 95-103
Journal: European Psychiatry - Volume 52, August 2018, Pages 95-103
نویسندگان
Paulina Wigner, Piotr Czarny, Ewelina Synowiec, MichaÅ Bijak, Monika Talarowska, Piotr Galecki, Janusz Szemraj, Tomasz Sliwinski,