کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8871291 1622701 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metal detoxification in the marine teleost fish Sparus aurata L. and Dicentrarchus labrax L.
موضوعات مرتبط
مهندسی و علوم پایه علوم زمین و سیارات اقیانوس شناسی
پیش نمایش صفحه اول مقاله
Metal detoxification in the marine teleost fish Sparus aurata L. and Dicentrarchus labrax L.
چکیده انگلیسی
Transcription of ATP-binding cassette (ABC) transporters has been evaluated in cell lines and primary cultures from gilthead seabream and European sea bass teleost fish exposed to methylmercury (MeHg), arsenic, cadmium or lead. The mRNA expression levels showed abcb1, abcc2 and abcc5 constitutive gene expression in all seabream tissues analyzed; however, we were unable to detect any constitutive transcription of abcb1 in many of the sea bass tissues. Furthermore, ABC mRNA expression levels were all affected by metal exposure, especially in the case of fish cell lines and erythrocytes, and greatly depended on cell type and fish species. Thus, while ABC transcription was up-regulated in the seabream cell line it was down-regulated in the sea bass cell line, while the opposite occurred in the primary cultures. All these data point to the importance of ABC transporters in metal detoxification and in the differential regulation in seabream and sea bass cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Marine Pollution Bulletin - Volume 133, August 2018, Pages 835-840
نویسندگان
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