Impact of Staphylococcus aureus phenotype and genotype on the clinical characteristics and outcome of infective endocarditis. AÂ multicentre, longitudinal, prospective, observational study

This is the first prospective study to assess the impact of S. aureus phenotype and genotype. Phenotype and genotype provided no additional predictive value beyond conventional clinical characteristics. No evidence was found to justify therapeutic decisions based on vancomycin MIC for either methicillin-resistant or methicillin-susceptible S. aureus.