کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8994969 | 1114479 | 2005 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural and Analytical Characterization of Three Hydrates and an Anhydrate Form of Risedronate
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Structural and Analytical Characterization of Three Hydrates and an Anhydrate Form of Risedronate Structural and Analytical Characterization of Three Hydrates and an Anhydrate Form of Risedronate](/preview/png/8994969.png)
چکیده انگلیسی
Four hydration states are reported for Risedronate monosodium. A single-crystal X-ray structure determination is provided as proof of assignment for the monohydrate, hemi-pentahydrate, and variable hydrate forms. The structure provided for the anhydrate form was determined through simulating annealing calculations and subsequent Reitveld refinement of a high-quality X-ray powder diffraction patterns Favorable comparisons of experimentally obtained X-ray powder patterns are made to those generated from the single crystal data. Characteristic infrared, Raman, and NMR spectra are provided and discussed for each form as are thermal analysis profiles. In addition, photomicrographs are provided for each of the forms isolated for this study. The hemi-pentahydrate is demonstrated to be the equilibrium form at room temperature and 37°C, in the presence of water.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 4, April 2005, Pages 893-911
Journal: Journal of Pharmaceutical Sciences - Volume 94, Issue 4, April 2005, Pages 893-911
نویسندگان
Nancy Redman-Furey, Michael Dicks, Adrienne Bigalow-Kern, R.Thomas Cambron, Gwen Lubey, Cathy Lester, Dana Vaughn,