کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9012728 1125004 2005 32 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent developments in cannabinoid ligands
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Recent developments in cannabinoid ligands
چکیده انگلیسی
Over the past 40 years, much research has been carried out directed toward the characterization of the cannabinergic system. With the identification of two G-protein coupled receptors and the endogenous ligand, anandamide, pharmacological targets have expanded to encompass hydrolase and transport proteins as well as novel classes of cannabinoid ligands. Those ligands that demonstrate high affinity for the receptors and good biological efficacy are tied together through lipophilic regions repeatedly demonstrated necessary for activity. This review presents recent developments in the structure-activity relationships of several classes of cannabinoid ligands.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 77, Issue 14, 19 August 2005, Pages 1767-1798
نویسندگان
,