کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016378 | 1128094 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
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کلمات کلیدی
NLHMK801PTZi.p.FLXNMDAN-methyl-d-aspartateCREBBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Seizure threshold - آستانه تشنجglutamate release - انتشار گلوتاماتlearned helplessness - بی تفاوتی آموختintraperitoneal - داخل صفاقیChronic treatment - درمان مزمنdizocilpine - دیسلوکپیپینBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزFluoxetine - فلوکستینselective serotonin reuptake inhibitors - مهار کننده های بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینHippocampus - هیپوکامپ cAMP responsive element binding protein - پروتئین اتصال دهنده عنصر پاسخ دهنده cAMPPentylenetetrazole - پنتیلن تترازول
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
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چکیده انگلیسی
The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two parameters of the hippocampal glutamatergic neurotransmission: the in vitro glutamate release and the binding of [3H] MK801 to NMDA receptors. While the acute treatment with FLX provoked no change either in seizure susceptibility or in the glutamate release, the chronic treatment decreased the convulsive threshold in coincidence with an increment in the in vitro glutamate release. No significant effects on the binding of [3H] MK801 to NMDA receptors were found to be attributable to the FLX treatment. We also assessed the effect of the chronic treatment with FLX on the seizure threshold in rats exposed to an experimental model of depression, the learned helplessness paradigm (LH). While a decrease in the K+-stimulated glutamate release was observed in non treated LH animals, when they were chronically injected with FLX, no changes in the epileptic susceptibility and no increments in the glutamate release were found. Our results indicate that chronic treatment with FLX decreases the epileptic threshold in naïve but not in LH rats and that this effect correlates with the levels of the hippocampal glutamate release.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 5, June 2005, Pages 678-686
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 5, June 2005, Pages 678-686
نویسندگان
Alejandro J. Ferrero, Marina Cereseto, AnalÃa Reinés, Carla D. Bonavita, Laura L. Sifonios, Modesto C. Rubio, Silvia I. Wikinski,