کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016400 | 1128094 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interferon-induced depression: Strategies in treatment
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کلمات کلیدی
5-HTSCIDMAOICHCALTMDDTCANSAIDCRHSJSAlanine aminotransferase - آلانین آمینوترانسفرازMajor depressive disorder - اختلال افسردگی عمدهDepression - افسردگیinterferon - اینترفرونIFN - اینترفرون هاtumor necrosis factor-α - تومور نکروز عامل αTricyclic antidepressant - داروهای ضدافسردگی سه حلقه ایSerotonin - سروتونینAntidepressant - ضدافسردگیNon-steroidal anti-inflammatory drug - غیر استروئیدی دارو ضد التهابیTNF-α - فاکتور نکروز توموری آلفاstructured clinical interview for DSM-IV - مصاحبه بالینی ساختاری برای DSM-IVSelective serotonin reuptake inhibitor - مهار کننده بازجذب سروتونین انتخابیmonoamine oxidase inhibitor - مهار کننده مونوآمین اکسیدازSSRI - مهارکنندههای بازجذب سروتونینHPA - میلی بار یا هکتوپاسکالcorticotrophin releasing hormone - هورمون آزاد کننده کورتیکوتروپینchronic hepatitis C - هپاتیت C مزمنhuman immunodeficiency virus - ویروس نقص ایمنی انسانیHIV - ویروس نقص ایمنی انسانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Interferon (IFN) is a pro-inflammatory cytokine that is widely used for the treatment of a number of disorders including viral infections, hematological proliferative disorders, and skin malignancies. Unfortunately, IFN frequently induced depression and has led to compromised tolerability with lowering of the dose of IFN and even discontinuation of treatment. Thus, it is imperative to diagnose IFN-induced depression early, evaluate whether this depression is associated with IFN-induced anemia or thyroid dysfunction, which can be corrected, and if necessary treat with antidepressants. IFN-induced depression is highly responsive to antidepressants with benefits occurring frequently at relatively low doses and after only a few weeks. Although SSRIs have mainly been studied, non-SSRIs appear to be effective also. Antidepressants have a number of risks and side effects that must be considered and may enter into the decision as to which antidepressant to choose. If IFN induces a depression in a patient with a bipolar disorder history, antidepressant treatment must include a mood stabilizer. In the case of vulnerable patients (e.g., those who have significant depressive symptoms prior to IFN or who have had an IFN-induced depression in the past) prophylactic antidepressant treatment appears to decrease the likelihood of having an IFN-induced depression. On the basis of known and effective treatment strategies, IFN-induced depression should not be an obstacle for continued treatment in most patient populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 5, June 2005, Pages 808-818
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 5, June 2005, Pages 808-818
نویسندگان
Gregory M. Asnis, Richard II,