کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016463 | 1128098 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study
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کلمات کلیدی
5-HTSNRIHDRSFGF2CREBGDNFBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Major depressive disorder - اختلال افسردگی عمدهcAMP response element binding - الگوریتم پاسخ cAMPSelective norepinephrine reuptake inhibitor - بازدارنده مجدد نوراپینفرین انتخابیSerotonine - سروتونینAntidepressant - ضدافسردگیGlial cell line-derived neurotrophic factor - فاکتور نوروتروفی مشتق از سلول گلیاییBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزfibroblast growth factor-2 - فیبروبلاست رشد فاکتور 2Hamilton Depression Rating Scale - مقیاس رتبه بندی افسردگی همیلتونSSRI - مهارکنندههای بازجذب سروتونینBiological marker - نشانگر بیولوژیکیnorepinephrine - نوراپی نفرینVenlafaxine - ونلافاکسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study The effect of chronic antidepressant treatment on serum brain-derived neurotrophic factor levels in depressed patients: a preliminary study](/preview/png/9016463.png)
چکیده انگلیسی
Recent studies suggested a role of brain-derived neurotrophic factor (BDNF) in depression. While BDNF levels are lower in depressed patients, antidepressant treatment increases serum BDNF levels of depressed patients. Our study aims to test the effect of chronic venlafaxine treatment on serum BDNF levels in patients with a major depressive disorder. Ten patients diagnosed as major depressive disorder according to DSM-IV are included in the study. Two of the patients had their first episode and were drug-naive, the other eight patients were drug-free for at least 4 weeks. The severity of depression was assessed with Hamilton Depression Rating Scale (HDRS). The control group consisted of ten age- and sex-matched subjects without any psychiatric disorder. Blood samples were collected at the baseline and after 12 weeks of antidepressant treatment (during remission). At the baseline the mean serum BDNF level was 17.9±9.1 ng/ml and the mean HDRS score was 23.2±4.6. Serum BDNF levels of the study group were significantly lower than in the control group (31.6±8.6 ng/ml). At the end of the study, the mean serum BDNF level was 34.6±7.1 ng/ml whereas the mean HDRS score was 8.2±3.9. From the baseline to the remission after 12 weeks of treatment, the increase in serum BDNF level and the decrease in HDRS score were statistically significant, respectively. When we compared the serum BDNF level of depressed patients at remission to that of the controls, there was no statistically significant difference. This study shows that venlafaxine treatment of depression improves serum BDNF level which may be considered as a nonspecific peripheral marker of depression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 2, February 2005, Pages 261-265
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 2, February 2005, Pages 261-265
نویسندگان
Omer Aydemir, Artuner Deveci, Fatma Taneli,