کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9016700 | 1128110 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Homocysteine and brain atrophy
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کلمات کلیدی
MTHFRWMHHcyN-methyl-d-aspartateNMDAMPTPBrain atrophy - آتروفی مغزیwhite matter hyperintensities - ابررایانه ماده سفیدSchizophrenia - اسکیزوفرنی یا شیزوفرنیFolic acid - اسید فولیکAlzheimer disease - بیماری آلزایمرAlzheimer's disease - بیماری آلزایمرParkinson disease - بیماری پارکینسونDementia - جنون یا زوال عقلMethylenetetrahydrofolate reductase - متیلن تتراهیدروفولات ردوکتازNeurotoxin - نوروتوکسینhomocysteine - هوموسیستئینOne carbon metabolism - یک متابولیسم کربن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Homocysteine (Hcy) has been implicated as a risk factor for vascular disease as well as brain atrophy. There is evidence to implicate Hcy in increased oxidative stress, DNA damage, the triggering of apoptosis and excitotoxicity, all important mechanisms in neurodegeneration. Hcy is also prothrombotic and proatherogenic, and causes damage to the vessel wall. It is related to brain atrophy in older individuals, and possibly to white matter hyperintensities (WMH) in the brain. Epidemiological evidence and longitudinal data support Hcy as a risk factor for cognitive impairment and Alzheimer's Disease (AD). This may be due to cerebrovascular as well as direct neurotoxic mechanisms. Its role in Parkinson Disease (PD) is less well supported. High Hcy has been suggested as a mediating factor in alcohol-related brain atrophy. The high prevalence of hyperhomocysteinemia in the population and its easy treatability make Hcy an interesting amino acid for future intervention studies in the prevention of degenerative brain disorders. Intervention studies are necessary to confirm its aetiological role.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 7, September 2005, Pages 1152-1161
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 29, Issue 7, September 2005, Pages 1152-1161
نویسندگان
Perminder S. Sachdev,