کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
904926 916899 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Douleur chronique : comorbidité anxiodépressive et ségrégation corticale
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Douleur chronique : comorbidité anxiodépressive et ségrégation corticale
چکیده انگلیسی
Chronic pain has deleterious consequences on the quality of life, including on mood. Indeed, depression and anxiety are often observed in chronic pain patients. While this comorbidity is clinically well-established, the underlying mechanisms remain to be detailed. In the recent years, the development of relevant preclinical animal models allowed determining causal relations between chronic pain and mood disorders. These models also provided mechanistic insights. Morphofunctional alterations in the anterior cingulate cortex, the nucleus accumbens and the hippocampus in neuropathic pain, some genetic polymorphisms and environmental factors in fibromyalgia, and changes in the balance between pro- and anti-inflammatory cytokines and the role of the amygdala in inflammatory pain, contribute to the anxiodepressive symptoms accompanying chronic pain. Data also suggest that different mechanisms may underlie the consequences of different types of chronic pain. Preclinical work also completes clinical data to understand the separated cortical processing of the various components of chronic pain, in particular, its sensory and its emotional components. Between the clinic and the lab, present translational effort allows progressing in understanding the pain/depression comorbidity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Douleurs : Evaluation - Diagnostic - Traitement - Volume 16, Issue 5, October 2015, Pages 226-237
نویسندگان
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