Differential central pain processing following repetitive intramuscular proton/prostaglandin E2 injections in female fibromyalgia patients and healthy controls

Repetitive proton/PGE2-induced excitation of muscle tissue led to a more prolonged perception of pain and more wide-spread activation in pain-related brain areas in FMS, especially in the left (ipsilateral) insula, whereas acute protons/PGE2-induced pain processing was similar in the two groups. These data provide further evidence for enhanced central pain processing in FMS patients.