کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
914151 | 918384 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)
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کلمات کلیدی
Chronic post-ischemia painIschemia-reperfusion injury - آسیب ایسکمی ـ باز خون رسانی یا آسیب ناشی از ایسکمی و برقراری مجدد جریان خونAllodynia - آلودینیا endothelin A receptor - اندوتلین گیرندهendothelin-1 - اندوتلین-1endothelin-2 - اندوتلین-2Neuropathic pain - درد نوروپاتیکReflex Sympathetic Dystrophy - دیستروفی سمپاتیک رفلکسendothelin B receptor - گیرنده اندوتلین B
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I) Role of peripheral endothelin receptors in an animal model of complex regional pain syndrome type 1 (CRPS-I)](/preview/png/914151.png)
چکیده انگلیسی
Chronic post-ischemic pain (CPIP) is an animal model of CRPS-I developed using a 3-h ischemia-reperfusion injury of the rodent hind paw. The contribution of local endothelin to nociception has been evaluated in CPIP mice by measuring sustained nociceptive behaviors (SNBs) following intraplantar injection of endothelin-1 or -2 (ET-1, ET-2). The effects of local BQ-123 (ETA-R antagonist), BQ-788 (ETB-R antagonist), IRL-1620 (ETB-R agonist) and naloxone (opioid antagonist) were assessed on ET-induced SNBs and/or mechanical and cold allodynia in CPIP mice. ETA-R and ETB-R expression was assessed using immunohistochemistry and Western blot analysis. Compared to shams, CPIP mice exhibited hypersensitivity to local ET-1 and ET-2. BQ-123 reduced ET-1- and ET-2-induced SNBs in both sham and CPIP animals, but not mechanical or cold allodynia. BQ-788 enhanced ET-1- and ET-2-induced SNBs in both sham and CPIP mice, and cold allodynia in CPIP mice. IRL-1620 displayed a non-opioid anti-nociceptive effect on ET-1- and ET-2-induced SNBs and mechanical allodynia in CPIP mice. The distribution of ETA-R and ETB-R was similar in plantar skin of sham and CPIP mice, but both receptors were over-expressed in plantar muscles of CPIP mice. This study shows that ETA-R and ETB-R have differing roles in nociception for sham and CPIP mice. CPIP mice exhibit more local endothelin-induced SNBs, develop a novel local ETB-R agonist-induced (non-opioid) analgesia, and exhibit over-expression of both receptors in plantar muscles, but not skin. The effectiveness of local ETB-R agonists as anti-allodynic treatments in CPIP mice holds promise for novel therapies in CRPS-I patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: PAIN - Volume 151, Issue 1, October 2010, Pages 174-183
Journal: PAIN - Volume 151, Issue 1, October 2010, Pages 174-183
نویسندگان
Magali Millecamps, Andre Laferrière, J. Vaigunda Ragavendran, Laura S. Stone, Terence J. Coderre,