کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
915541 1473257 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients
چکیده انگلیسی

Previous experiments found that placebos produced small decreases in neural activity of pain-related areas of the brain, yet decreases were only statistically significant after termination of stimuli and in proximity to when subjects rated them. These changes could reflect report bias rather than analgesia. This functional magnetic resonance imaging (fMRI) study examined whether placebo analgesia is accompanied by reductions in neural activity in pain-related areas of the brain during the time of stimulation. Brain activity of irritable bowel syndrome patients was measured in response to rectal distension by a balloon barostat. Large reductions in pain and in brain activation within pain-related regions (thalamus, somatosensory cortices, insula, and anterior cingulate cortex) occurred during the placebo condition. Results indicate that decreases in activity were related to placebo suggestion and a second factor (habituation/attention/conditioning). Although many factors influence placebo analgesia, it is accompanied by reduction in pain processing within the brain in clinically relevant conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pain - Volume 127, Issues 1–2, January 2007, Pages 63–72
نویسندگان
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