کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9157934 | 1172472 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulation of cholesterol 7α-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet
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کلمات کلیدی
CYP7A1ABC, ATP-binding cassette transporterATP-binding cassette transporter A1 - ATP اتصال گیرنده کاست A1farnesoid X receptor - Farnesoid X گیرندهFXR, farnesoid X receptor - FXR، گیرنده Farnesoid XGAPDH, glyceraldehyde-3-phosphate dehydrogenase - GAPDH، glyceraldehyde-3-phosphate dehydrogenaseLXR, liver X receptor - LXR، گیرنده کبد XPXR, pregnane X receptor - PXR، گیرنده حامل XCholic acid - اسید چلیکliver X receptor - کبد X گیرندهshort heterodimer partner - کوتاه همکار
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Regulation of cholesterol 7α-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet Regulation of cholesterol 7α-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet](/preview/png/9157934.png)
چکیده انگلیسی
The nuclear receptors liver X receptor (LXR) α and farnesoid X receptor (FXR) are positive and negative regulators of cholesterol 7α-hydroxylase (CYP7A1) transcription, respectively. To clarify their roles in the regulation of CYP7A1 in mice, we investigated mRNA expression of their target genes in the livers of C57BL/6 mice fed the following five diets for 2 weeks: a standard diet, cholic acid, cholesterol, cholesterol + high fat, or an atherogenic diet (cholic acid + cholesterol + high fat). The mRNA level of ATP-binding cassette transporter (ABC) A1 gene, one of LXRα target genes, significantly increased on the diets containing cholic acid and/or cholesterol + high fat, but not on the diet containing cholesterol alone. On the other hand, the mRNA levels of the FXR target genes ABCB11, ABCC2, and short heterodimer partner increased only on the diet containing cholic acid with or without cholesterol + high fat. Surprisingly, cholesterol alone or cholesterol + high fat did not affect CYP7A1 mRNA level, whereas cholic acid with or without cholesterol + high fat greatly reduced the level. Thus, in the atherogenic diet-fed mice, cholic acid component is needed for the FXR activation, and FXR dominantly regulates CYP7A1 transcription.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Atherosclerosis - Volume 178, Issue 2, February 2005, Pages 265-269
Journal: Atherosclerosis - Volume 178, Issue 2, February 2005, Pages 265-269
نویسندگان
Hitoshi Ando, Shuichi Tsuruoka, Hisashi Yamamoto, Toshinari Takamura, Shuichi Kaneko, Akio Fujimura,