Vieillissement cutané chronologique

Cutaneous chronologic aging is a complex phenomenon which is genetically programmed, with a deleterious effect due to free oxygen radicals generated in the organism. The clinical presentation consists of skin atrophy with cutaneous weakness, dryness, elasticity loss, marked wrinkles and numerous functional modifications associated with a decreased immune response. Histologically, chronologic aging induces a decrease in epidermal thickness with a flattening of dermo-epidermal junction, a dermal atrophy with collagen decrease, elastic fibre elastolysis and microcirculation alterations.