کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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922586 | 921050 | 2011 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Aerobic fitness is associated with lower proportions of senescent blood T-cells in man Aerobic fitness is associated with lower proportions of senescent blood T-cells in man](/preview/png/922586.png)
Senescent T-cells accumulate with age, lowering the naïve T-cell repertoire and increasing host infection risk. As this response is likely to be influenced by certain lifestyle factors, we examined the association between aerobic fitness (V˙O2max) and the age-related accumulation of senescent T-cells. Blood lymphocytes from 102 healthy males (18–61 yr) were analyzed for KLRG1, CD57, CD28, CD45RA, CD45RO surface expression on CD4+ and CD8+ T-cells by 4-color flow cytometry. Advancing age (yr) was positively associated with the proportion (%) of senescent (KLRG1+/CD57+; KLRG1+/CD28−) CD4+ (B = 1.00; 1.02) and CD8+ (B = 0.429; 1.02) T-cells and inversely associated with naïve (KLRG1−/CD28+) CD4+ (B = −1.000) and CD8+ (B = −0.993) T-cells. V˙O2max was inversely associated with senescent CD4+ (B = −0.97) and CD8+ (B = −0.240). Strikingly, age was no longer associated with the proportions of senescent or naïve T-cells after adjusting for V˙O2max, while the association between V˙O2max and these T-cell subsets withstood adjustment for age, BMI and percentage body fat. Ranking participants by age-adjusted V˙O2max revealed that the highest tertile had 17% more naïve CD8+ T-cells and 57% and 37% less senescent CD4+ and CD8+ T-cells, respectively, compared to the lowest tertile. V˙O2max was not associated with latent cytomegalovirus (CMV), Epstein-Barr virus (EBV) or herpes simplex virus-1 (HSV-1) infection, indicating that the moderating associations of V˙O2max were not confounded by persistent viral infections. This is the first study to show that aerobic fitness is associated with a lower age-related accumulation of senescent T-cells, highlighting the beneficial effects of maintaining a physically active lifestyle on the aging immune system.
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► Aerobic fitness is associated with lower proportions of senescent T-cells independently of age, highlighting the beneficial effects of fitness on the aging immune system.
Journal: Brain, Behavior, and Immunity - Volume 25, Issue 8, November 2011, Pages 1521–1529