کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9230064 1587823 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی امراض پوستی
پیش نمایش صفحه اول مقاله
Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging
چکیده انگلیسی
The purpose of this article is to offer perspective on current understanding of ultraviolet (UV) irradiation-induced signal transduction, with emphasis on membrane-initiated, non-nuclear signaling events. We will describe the role of UV-induced signaling in the mechanism of premature skin aging (photoaging). UV irradiation serves as a universal ligand to active cell surface receptors and to induce assembly of signaling complexes at the plasma membrane. These complexes activate cytosolic protein kinase cascades that relay signals to the cell nucleus, thereby regulating the activity of a variety transcription factors. Key cellular responses are up-regulation of matrix-degrading metalloproteinases, and down-regulation of extracellular matrix biosynthesis. The resultant net deficit of structural integrity of skin connective tissue is one of the major factors that contributes to the phenotype of photoaging. Insights into the molecular mechanisms of UV-induced signal transduction will eventually translate into new, effective methods to prevent UV-induced skin damage.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science Supplement - Volume 1, Issue 2, December 2005, Pages S1-S8
نویسندگان
, ,