کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9230067 | 1587823 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tissue-specific downregulation of type VII collagen gene (COL7A1) transcription in cultured epidermal keratinocytes by ultraviolet A radiation (UVA) and UVA-inducible cytokines, with special reference to cutaneous photoaging
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tissue-specific downregulation of type VII collagen gene (COL7A1) transcription in cultured epidermal keratinocytes by ultraviolet A radiation (UVA) and UVA-inducible cytokines, with special reference to cutaneous photoaging Tissue-specific downregulation of type VII collagen gene (COL7A1) transcription in cultured epidermal keratinocytes by ultraviolet A radiation (UVA) and UVA-inducible cytokines, with special reference to cutaneous photoaging](/preview/png/9230067.png)
چکیده انگلیسی
UVA, TNF-α and IL-1β inhibit COL7A1 expression at the transcriptional level by acting on nucleotides â524 to â22 of the promoter region. These results suggest that UVA-induced downregulation of COL7A1 transcription in epidermal keratinocytes diminishes anchoring fibrils formation, resulting in skin fragility. Additional external factors including physical forces and UVB radiation in the sun-exposed areas may further promote deep wrinkle formation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Dermatological Science Supplement - Volume 1, Issue 2, December 2005, Pages S29-S35
Journal: Journal of Dermatological Science Supplement - Volume 1, Issue 2, December 2005, Pages S29-S35
نویسندگان
Atsushi Kon, Hitoshi Takeda, Noriko Ito, Katsumi Hanada, Keiichi Takagaki,