کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9267835 | 1218805 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tumor necrosis factor-alpha â308 promoter polymorphism contributes independently to HLA alleles in the severity of rheumatoid arthritis in Mexicans
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The aim of this study was to determine the frequency and potential relevance of the promoter polymorphisms of the tumor necrosis factor-alpha (TNF-α) in the severity of rheumatoid arthritis (RA) in Mexicans. HLA-DR and polymorphisms at positions â238 and â308 of TNF-α gene were determined in 137 Mexican RA patients (44 with severe and 93 with non-severe RA) as well as in 169 healthy controls (99 were typed for HLA-DR). We observed an increased frequency of HLA-DR4 in severe RA compared to healthy controls (pC = 0.02, OR = 2.33). TNF polymorphism analysis showed a significant increased frequency of TNF â238 GG genotype in the whole group of RA patients when compared to healthy controls (pC = 0.007, OR = 4.71). When the analyses were carried out separately in severe and non-severe RA patients, the increased frequency of â238 GG genotype only was observed in patients with non-severe forms of the disease. Analysis of â308 polymorphism showed increased frequency of â308 T2 (A) allele in severe RA when compared to non-severe disease (pC = 0.011, OR = 3.29) and to healthy controls (pC = 0.002, OR = 3.97). The data demonstrate that â308 T2 (A) allele is associated with susceptibility to develop severe RA in Mexicans. This association could be independent from HLA-DR alleles and might be used as a prognostic marker for severe RA.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 24, Issue 1, February 2005, Pages 63-68
Journal: Journal of Autoimmunity - Volume 24, Issue 1, February 2005, Pages 63-68
نویسندگان
Alma Angelica RodrÃguez-Carreón, JoaquÃn Zúñiga, Guadalupe Hernández-Pacheco, José Manuel RodrÃguez-Pérez, Nonanzit Pérez-Hernández, Jose Vicente Montes de Oca, Mario H. Cardiel, Julio Granados, Gilberto Vargas-Alarcón,