کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9267836 | 1218805 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential regulation of Cu, Zn- and Mn-superoxide dismutases by retinoic acid in normal and psoriatic human fibroblasts
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کلمات کلیدی
GAPDHpKaPDGFCRABPIId-glyceraldehyde-3-phosphate dehydrogenase - D-گلیسرالیدید-3-فسفات دهیدروژنازROS - ROSFree radicals - رادیکال آزادRetinoic acid - رتینوئیک اسیدSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازsuperoxide dismutases - سوکسوکس دیسموتازهاplatelet derived growth factor - فاکتور رشد حاصل از پلاکتFibroblasts - فیبروبلاست هاprotein kinase A - پروتئین کیناز APsoriasis - پسوریازیسReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Superoxide dismutases' (SODs) expression is altered in several diseases including Alzheimer, atherosclerosis, cancer and psoriasis. Previously, we reported a marked increase in Mn-SOD and Cu,Zn-SOD functional activity in human dermal psoriatic fibroblasts. As retinoic acid (RA) has been used in the treatment of psoriasis and a mechanism for its beneficial effects is not understood, we investigated the effects of RA on SOD mRNA and protein expression levels in human normal and psoriatic fibroblasts. Prior to RA exposure, Cu,Zn-SOD protein and mRNA levels were similar in normal compared to psoriatic fibroblasts while Mn-SOD protein and mRNA levels were increased in psoriatic cells. However, in contrast to normal fibroblasts, exposure of psoriatic fibroblasts to 1 μM RA down-regulated Mn-SOD mRNA, and also decreased Mn-SOD activity by â¼80% with no change in Mn-SOD protein levels. In contrast, Cu,Zn-SOD protein and enzymatic activity were modestly reduced by RA treatment in both normal and psoriatic fibroblasts. Furthermore, RA treatment of psoriatic fibroblasts also caused a decrease in Cu,Zn-SOD steady-state mRNA levels. These results indicate that RA can serve as a regulatory agent to down-regulate the steady-state levels of both Mn-SOD and Cu,Zn-SOD in psoriatic cells. These findings offer a new model for the antiinflammatory activity of RA when used in the treatment of psoriasis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 24, Issue 1, February 2005, Pages 69-78
Journal: Journal of Autoimmunity - Volume 24, Issue 1, February 2005, Pages 69-78
نویسندگان
Pascale Gerbaud, Loïc Petzold, Patrice Thérond, Wayne B. Anderson, Danièle Evain-Brion, Françoise Raynaud,