کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9273521 | 1221081 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dwindling competition with constant demand: Can homeostatic adjustments explain age-associated changes in peripheral B cell selection?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The close relationship between specificity-based selection and homeostatic processes in maintaining peripheral B cell pools has become increasingly evident. Thus, age-associated changes observed within these pools may reflect homeostatic responses to proximal primary lesions. Marked shifts in the size and dynamics of most B lymphocyte subsets and their progenitors occur with age: perturbations in B lineage precursors result in reduced production of immature B lymphocytes in the bone marrow and transitional pools in the periphery, but these effects appear to be offset by compensatory homeostatic processes at the marrow-periphery interface. We propose a model whereby these “distal” homeostatic adjustments relax the stringency of specificity based selection, affording a potential explanation for the increased frequency of autoreactive specificities with age.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 17, Issue 5, October 2005, Pages 362-369
Journal: Seminars in Immunology - Volume 17, Issue 5, October 2005, Pages 362-369
نویسندگان
William J. III, Jean L. Scholz, Michael P. Cancro,