کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9282887 | 1593662 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts
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کلمات کلیدی
TNFαIL-6IFNγnatural killer - (سلول های) کشنده طبیعیStreptococcus pneumoniae - استرپتوکوک پنومونیهinterleukin-6 - اینترلوکین ۶BALF - بافتBacteraemia - باکتریمیtumour necrosis factor alpha - تومور نکروز عامل آلفاPneumonia - ذات الریهNatural killer cells - سلولهای کشنده طبیعیBronchoalveolar lavage fluid - مایع لارو برونکلوفلورInterferon gamma - گاما اینترفرون
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Gram-positive sepsis is a major disease problem. However, the contribution of various immune cell types to pathogenesis remains unclear. By infecting scid and wild type BALB/c mice with Streptococcus pneumoniae we have found a situation in which natural killer (NK) cells can play a detrimental role in the response to infection. scid mice were found to be significantly more susceptible to local and systemic pneumococcal infection than controls; they had significantly higher bacterial loads, elevated inflammatory responses and more widespread lung pathology. Interestingly, depletion of NK cells in scid mice resulted in significantly lower bacteraemia and inflammatory cytokine production. Infection with pneumococci deficient in pneumolysin revealed the toxin was involved in cytokine production. Overall results indicate that elevated NK cell activity during pneumococcal pneumonia amplifies pulmonary and systemic inflammation, increases bacteraemia and results in poor outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Microbes and Infection - Volume 7, Issues 5â6, May 2005, Pages 845-852
Journal: Microbes and Infection - Volume 7, Issues 5â6, May 2005, Pages 845-852
نویسندگان
Alison R. Kerr, Lea Ann S. Kirkham, Aras Kadioglu, Peter W. Andrew, Paul Garside, Hal Thompson, Tim J. Mitchell,