کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918828 | 1557559 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
Polylactic acid (PLA-l) microspheres were prepared as a biodegradable polymeric carrier for a non-steroidal anti-inflammatory drug, nimesulide. The preparation of this system was performed by the classical emulsion solvent-evaporation method. Size analysis of the microparticulate system showed that unloaded and loaded nimesulide-PLA microspheres had average diameters of about 42.9 nm and 2.1 μm, respectively. Scanning electron microscopy (SEM) of loaded and unloaded microsphere samples showed that the particles shape were perfectly spherical, the loading efficiency of nimesulide in PLA microspheres was 70%; Thus, the microparticle system evaluated in this work showed the potential to act as a sustained release system for nimesulide: in vitro dissolution profiles showed the PLA-l microparticles were able to sustain the release of the drug for a considerable period of time (28.7% within 108 h).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 295, Issues 1â2, 13 May 2005, Pages 201-211
Journal: International Journal of Pharmaceutics - Volume 295, Issues 1â2, 13 May 2005, Pages 201-211
نویسندگان
M.N. Freitas, J.M. Marchetti,