کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918846 | 1557560 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characteristics of interpolyelectrolyte complexes of Eudragit E 100 with sodium alginate
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
With a view to the application in oral drug delivery formulations, the possibility to form interpolyelectrolyte complexes (IPEC) of Eudragit E 100 (EE) with sodium alginate (AL) was investigated, employing turbidimetry, apparent viscosity measurements, FT-IR and elementary analysis. The interaction or binding ratio of a unit molecule of AL with EE was largely affected by the pH value of the media, showing a change from 1.5:1 to 1:1.25 (0.66Â <Â ZÂ <Â 1.25) with increase in pH value from 2.5 to 6.0. Based on the results of elementary analysis and FT-IR, the interaction ratio of each component in the solid complexes was very close to that observed in turbidity and apparent viscosity measurements thus proving that the synthesized products actually can be considered as IPEC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 294, Issues 1â2, 27 April 2005, Pages 113-120
Journal: International Journal of Pharmaceutics - Volume 294, Issues 1â2, 27 April 2005, Pages 113-120
نویسندگان
R.I. Moustafine, V.A. Kemenova, G. Van den Mooter,