کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9989592 | 1580761 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse Cystatin C modulates neurodegeneration and neurogenesis following status epilepticus in mouse](/preview/png/9989592.png)
چکیده انگلیسی
Brain damaging insults cause alterations in neuronal networks that trigger epileptogenesis, and eventually lead to the appearance of spontaneous seizures. The present experiments were designed to study the cellular expression and functions of a cysteine proteinase inhibitor, cystatin C, whose gene expression is previously shown to be upregulated in the rat hippocampus during status epilepticus (SE)-induced epileptogenesis. The present data showed that the expression of cystatin C protein increased in the mouse hippocampus 7 days following SE and localized mainly to astrocytes and microglia. Acute neuronal death in the hippocampus at 24 h after SE was reduced in cystatin Câ/â mice. Also, the basal level of neurogenesis in the subgranular layer of dentate gyrus was decreased in cystatin Câ/â mice compared to wildtype littermates. Interestingly, migration of newly born neurons within the granule cell layer was attenuated in cystatin Câ/â mice. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 20, Issue 2, November 2005, Pages 241-253
Journal: Neurobiology of Disease - Volume 20, Issue 2, November 2005, Pages 241-253
نویسندگان
Terhi J. Pirttilä, Katarzyna Lukasiuk, Katarina HÃ¥kansson, Anders Grubb, Magnus Abrahamson, Asla Pitkänen,