Dual serotonin transporter inhibitor/histamine H3 antagonists: Development of rigidified H3 pharmacophores Fulltext Access 5 Pages 2007
Synthesis of neuroprotective cyclopentenone prostaglandin analogs: Suppression of manganese-induced apoptosis of PC12 cells Fulltext Access 5 Pages 2007
Potent, nonsteroidal selective androgen receptor modulators (SARMs) based on 8H-[1,4]oxazino[2,3-f]quinolin-8-ones Fulltext Access 5 Pages 2007
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of cinnamyl compounds as potent antitumor agents Fulltext Access 5 Pages 2007
3,3-Diphenylpentane skeleton as a steroid skeleton substitute: Novel inhibitors of human 5α-reductase 1 Fulltext Access 5 Pages 2007
Alkanethiol containing glycopolymers: A tool for the detection of lectin binding Fulltext Access 5 Pages 2007
Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase Fulltext Access 5 Pages 2007
Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA Fulltext Access 5 Pages 2007
Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile Fulltext Access 5 Pages 2007
Design, synthesis and biological evaluation of 1,4-benzodiazepine-2,5-dione-based HDAC inhibitors Fulltext Access 5 Pages 2007
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida Fulltext Access 5 Pages 2007
Antinociceptive activity of furan-containing congeners of improgan and ranitidine Fulltext Access 5 Pages 2007
2-Benzenesulfonyl-8a-benzyl-hexahydro-2H-isoquinolin-6-ones as selective glucocorticoid receptor antagonists Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production Fulltext Access 5 Pages 2007
Synthesis and characterization of a pegylated derivative of 3-(1,2,3,6-tetrahydro-pyridin-4yl)-1H-indole (IDT199): A high affinity SERT ligand for conjugation to quantum dots Fulltext Access 5 Pages 2007
Conformationally restricted homotryptamines. Part 4: Heterocyclic and naphthyl analogs of a potent selective serotonin reuptake inhibitor Fulltext Access 5 Pages 2007
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization Fulltext Access 5 Pages 2007
Preparative purification of polyethylene glycol derivatives with polystyrene-divinylbenzene beads as chromatographic packing Fulltext Access 5 Pages 2007
Effect of the minor ABA metabolite 7′-hydroxy-ABA on Arabidopsis ABA 8′-hydroxylase CYP707A3 Fulltext Access 5 Pages 2007
Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2 Fulltext Access 5 Pages 2007
Synthesis of benzothiazole semicarbazones as novel anticonvulsants—The role of hydrophobic domain Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of 9-deazaguanine derivatives connected by a linker to difluoromethylene phosphonic acid as multi-substrate analogue inhibitors of PNP Fulltext Access 5 Pages 2007
5(Z)-Benzylidene-1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-1-aza-6-oxa-chrysenes as non-steroidal glucocorticoid receptor modulators Fulltext Access 5 Pages 2007
Natural feruloyl monoglyceride macrocycles as protecting factors against free-radical damage of lipidic membranes Fulltext Access 5 Pages 2007
Synthesis and antitumour activity of new tiazofurin analogues bearing a 2,3-anhydro functionality in the furanose ring Fulltext Access 5 Pages 2007
Bicyclo[2.2.2]octanes: Close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators Fulltext Access 5 Pages 2007
Synthesis and antiproliferative activity of thiazolidine analogs for melanoma Fulltext Access 5 Pages 2007
Synthesis and evaluation of amphiphilic cationic quinine-derived for antibacterial activity against methicillin-resistant Staphylococcus aureus Fulltext Access 5 Pages 2007
Orally active antimalarials: Synthesis and bioevaluation of a new series of steroid-based 1,2,4-trioxanes against multi-drug resistant malaria in mice Fulltext Access 5 Pages 2007
New fluoro-diphenylchalcogen derivatives to explore the serotonin transporter by PET Fulltext Access 5 Pages 2007
Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK Fulltext Access 5 Pages 2007
On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition Fulltext Access 5 Pages 2007
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium) Fulltext Access 5 Pages 2007
Dumbbell-shaped circular oligonucleotides as inhibitors of human topoisomerase I Fulltext Access 5 Pages 2007
Experimental and theoretical study on the structure and electronic spectra of imiquimod and its synthetic intermediates Fulltext Access 5 Pages 2007
The identification of potent, selective, and bioavailable cathepsin S inhibitors Fulltext Access 5 Pages 2007
Eco-friendly synthesis and study of new plant growth promoters: 3,3′-Diindolylmethane and its derivatives Fulltext Access 5 Pages 2007
Discovery and optimization of novel, non-steroidal glucocorticoid receptor modulators Fulltext Access 5 Pages 2007
Synthesis and binding affinity of new pyrazole and isoxazole derivatives as potential atypical antipsychotics Fulltext Access 5 Pages 2007
4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors Fulltext Access 5 Pages 2007
Benzopyrans as selective estrogen receptor β agonists (SERBAs). Part 3: Synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification Fulltext Access 5 Pages 2007
The triphosphate of β-d-4′-C-ethynyl-2′,3′-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase Fulltext Access 5 Pages 2007
Preparation of N-tBoc l-glutathione dimethyl and di-tert-butyl esters: Versatile synthetic building blocks Fulltext Access 5 Pages 2007
I-motif and quadruplex-based device that can control a protein release or bind and release small molecule to influence biological processes Fulltext Access 5 Pages 2007
Carinatumins A–C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase Fulltext Access 5 Pages 2007
Improved automated synthesis of [18F]fluoroethylcholine as a radiotracer for cancer imaging Fulltext Access 5 Pages 2007
Na+-Glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens Fulltext Access 5 Pages 2007
Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers Fulltext Access 5 Pages 2007
Cytochrome P-450 model reactions: Efficient and highly selective oxidation of alcohols with tetrabutylammonium peroxymonosulfate catalyzed by Mn-porphyrins Fulltext Access 5 Pages 2007
The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum Fulltext Access 5 Pages 2007
Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum Fulltext Access 5 Pages 2007
Design and evaluation of analogues of the bacterial cell-wall peptidoglycan motif l-Lys-d-Ala-d-Ala for use in a vancomycin biosensor Fulltext Access 5 Pages 2007
Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV Fulltext Access 5 Pages 2007
Structure–activity relationship and biological property of cortistatins, anti-angiogenic spongean steroidal alkaloids Fulltext Access 5 Pages 2007
Bioassay-guided fractionation of pterocarpans from roots of Harpalyce brasiliana Benth Fulltext Access 5 Pages 2007
Natural bromophenols from the marine red alga Polysiphonia urceolata (Rhodomelaceae): Structural elucidation and DPPH radical-scavenging activity Fulltext Access 5 Pages 2007
Synthesis, characterization and antimicrobial activity of new aliphatic sulfonamide Fulltext Access 5 Pages 2007
Synthesis and antiproliferative activity of clausine E, mukonine, and koenoline bioisosteres Fulltext Access 5 Pages 2007
Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins Fulltext Access 5 Pages 2007
Caco-2 cell permeability and stability of two d-glucopyranuronamide conjugates of thyrotropin-releasing hormone Fulltext Access 5 Pages 2007
Optimizing the enzymatic synthesis of β-d-galactopyranosyl-d-xyloses for their use in the evaluation of lactase activity in vivo Fulltext Access 5 Pages 2007
Emission of characteristic fluorescence from the ligand–cytosine complex in U_A/ACU bulged RNA duplex Fulltext Access 5 Pages 2007
Tandem ligation at X-Cys and Gly-Gly positions via an orthogonally protected auxiliary group Fulltext Access 5 Pages 2007
Inactivation of soybean sterol 24-C-methyltransferase by elongated sterol side chains at C26 Fulltext Access 5 Pages 2007
Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase Fulltext Access 5 Pages 2007
Discovery of (−)-6-[2-[4-(3-fluorophenyl)-4-hydroxy-1-piperidinyl]-1-hydroxyethyl]-3,4-dihydro-2(1H)-quinolinone—A potent NR2B-selective N-methyl d-aspartate (NMDA) antagonist for the treatment of pain Fulltext Access 5 Pages 2007
Novel steroidal saponins, Sch 725737 and Sch 725739, from a marine starfish, Novodinia antillensis Fulltext Access 5 Pages 2007
Solid-phase synthesis and thermal denaturation study of cyclic PNAs targeting the HIV-1 TAR RNA loop Fulltext Access 5 Pages 2007
Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors Fulltext Access 5 Pages 2007
Synthesis and structure–activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors Fulltext Access 5 Pages 2007
An effective method for the in situ synthesis of DNA-CPG conjugates using chemical ligation technology as tools for SNP analysis Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists Fulltext Access 5 Pages 2007
Fluorinated chloramphenicol acetyltransferase thermostability and activity profile: Improved thermostability by a single-isoleucine mutant Fulltext Access 5 Pages 2007
Design, synthesis, and biological testing of pyrazoline derivatives of combretastatin-A4 Fulltext Access 5 Pages 2007
NO donors. Part 16: Investigations on structure–activity relationships of organic mononitrates reveal 2-nitrooxyethylammoniumnitrate as a high potent vasodilator Fulltext Access 5 Pages 2007
Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors Fulltext Access 5 Pages 2007
Synthesis and inhibitory activity of 4-alkynyl and 4-alkenylquinazolines: Identification of new scaffolds for potent EGFR tyrosine kinase inhibitors Fulltext Access 5 Pages 2007
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes Fulltext Access 5 Pages 2007
Strategies toward improving the brain penetration of macrocyclic tertiary carbinamine BACE-1 inhibitors Fulltext Access 5 Pages 2007
d-Phenylglycinol-derived non-covalent factor Xa inhibitors: Effect of non-peptidic S4 linkage elements on affinity and anticoagulant activity Fulltext Access 5 Pages 2007
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan® Fulltext Access 5 Pages 2007
Convenient synthesis of indeno[1,2-c]isoquinolines as constrained forms of 3-arylisoquinolines and docking study of a topoisomerase I inhibitor into DNA–topoisomerase I complex Fulltext Access 5 Pages 2007