Synthesis and SAR of 3,5-diamino-piperidine derivatives: Novel antibacterial translation inhibitors as aminoglycoside mimetics Fulltext Access 5 Pages 2007
Potent, selective, and orally active adenosine A2A receptor antagonists: Arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of new conformationally biased integrin ligands based on a tetrahydroazoninone scaffold Fulltext Access 5 Pages 2007
Carbonic anhydrase activators: An activation study of the human mitochondrial isoforms VA and VB with amino acids and amines Fulltext Access 5 Pages 2007
Diastereoselective synthesis of glycosylated prolines as α-glucosidase inhibitors and organocatalyst in asymmetric aldol reaction Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists Fulltext Access 5 Pages 2007
Rational design, synthesis, and structure–activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure Fulltext Access 5 Pages 2007
Synthesis, characterization, antibacterial activity, and interaction with DNA of the vanadyl-enrofloxacin complex Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors Fulltext Access 5 Pages 2007
Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans Fulltext Access 5 Pages 2007
In vitro selection of RNA aptamer against Escherichia coli release factor 1 Fulltext Access 5 Pages 2007
Discovery and preliminary evaluation of 5-(4-phenylbenzyl)oxazole-4-carboxamides as prostacyclin receptor antagonists Fulltext Access 5 Pages 2007
Structural simplification of bioactive natural products with multicomponent synthesis: Dihydropyridopyrazole analogues of podophyllotoxin Fulltext Access 5 Pages 2007
Chiral tetrahydroquinoline derivatives as potent anti-hyperalgesic agents in animal models of sustained inflammation and chronic neuropathic pain Fulltext Access 5 Pages 2007
Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells Fulltext Access 5 Pages 2007
Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives Fulltext Access 5 Pages 2007
Design, synthesis, and bioactivity of novel inhibitors of E. coli aspartate transcarbamoylase Fulltext Access 5 Pages 2007
Advantages and limitation of BODIPY as a probe for the evaluation of lipid peroxidation and its inhibition by antioxidants in plasma Fulltext Access 5 Pages 2007
Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists Fulltext Access 5 Pages 2007
An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of unprecedented classes of spiro-β-lactams and azido-β-lactams as acyl-CoA:cholesterol acyltransferase inhibitors Fulltext Access 5 Pages 2007
Glucosamine sulfate promotes osteoblastic differentiation of MG-63 cells via anti-inflammatory effect Fulltext Access 5 Pages 2007
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes Fulltext Access 5 Pages 2007
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure–activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives Fulltext Access 5 Pages 2007
Binding mode and affinity studies of DNA-binding agents using topoisomerase I DNA unwinding assay Fulltext Access 5 Pages 2007
A convenient and efficient protocol for oxidative aromatization of Hantzsch 1,4-dihydropyridines using benzyltriphenylphosphonium peroxymonosulfate under almost neutral reaction conditions Fulltext Access 5 Pages 2007
Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities Fulltext Access 5 Pages 2007
A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds Fulltext Access 5 Pages 2007
Discovery of (Z)-2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives active against Haemonchus contortus and Ctenocephalides felis (cat flea) Fulltext Access 5 Pages 2007
Efficient synthesis of substituted 7-methyl-2H,5H-pyrano[4,3-b]pyran-5-ones and evaluation of their in vitro antiproliferative/cytotoxic activities Fulltext Access 5 Pages 2007
13C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester Fulltext Access 5 Pages 2007
Synthesis and antimalarial evaluation of a series of piperazinyl flavones Fulltext Access 5 Pages 2007
Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates Fulltext Access 5 Pages 2007
Design and synthesis of oxime ethers of α-acyl-β-phenylpropanoic acids as PPAR dual agonists Fulltext Access 5 Pages 2007
The crystal structure, self-assembly, DNA-binding and cleavage studies of the [2]pseudorotaxane composed of cucurbit[6]uril Fulltext Access 5 Pages 2007
Production of aminoglycosides in non-aminoglycoside producing Streptomyces lividans TK24 Fulltext Access 5 Pages 2007
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: Differences of bioactivity in the enantiomeric series Fulltext Access 5 Pages 2007
ERβ ligands. Part 5: Synthesis and structure–activity relationships of a series of 4′-hydroxyphenyl-aryl-carbaldehyde oxime derivatives Fulltext Access 5 Pages 2007
Design and synthesis of 3,5-disubstituted benzamide analogues of DNK333 as dual NK1/NK2 receptor probes Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli β-ketoacyl-ACP-synthase III (FabH) Fulltext Access 5 Pages 2007
An evaluation of 3,4-methylenedioxy phenyl replacements in the aminopiperidine chromone class of MCHr1 antagonists Fulltext Access 5 Pages 2007
Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents Fulltext Access 5 Pages 2007
Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Aβ fibril formation Fulltext Access 5 Pages 2007
Synthesis and structure–activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP Fulltext Access 5 Pages 2007
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE) Fulltext Access 5 Pages 2007
A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE Fulltext Access 5 Pages 2007
Discovery and SAR study of novel dihydroquinoline-containing glucocorticoid receptor agonists Fulltext Access 5 Pages 2007
4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation Fulltext Access 5 Pages 2007
Pentamer is the minimum structure for oligomannosylpeptoids to bind to concanavalin A Fulltext Access 5 Pages 2007
A novel ketolide class: Synthesis and antibacterial activity of a lead compound Fulltext Access 5 Pages 2007
Synthesis and optimization of novel and selective muscarinic M3 receptor antagonists Fulltext Access 5 Pages 2007
PASS-predicted design, synthesis and biological evaluation of cyclic nitrones as nootropics Fulltext Access 5 Pages 2007
Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: Synthesis and in vitro evaluation Fulltext Access 5 Pages 2007
Theoretical calculation of the binding free energies for pyruvate dehydrogenase E1 binding with ligands Fulltext Access 5 Pages 2007
Anti-inflammatory property of the urinary metabolites of nobiletin in mouse Fulltext Access 5 Pages 2007
Discovery of a highly potent series of oxazole-based phosphodiesterase 4 inhibitors Fulltext Access 5 Pages 2007
Carbonic anhydrase inhibitors: Selective inhibition of the extracellular, tumor-associated isoforms IX and XII over isozymes I and II with glycosyl-thioureido-sulfonamides Fulltext Access 5 Pages 2007
Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties Fulltext Access 5 Pages 2007
Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells Fulltext Access 5 Pages 2007
A host-rotaxane derivatized with carboxylic acids efficiently delivers a highly cationic fluoresceinated peptide Fulltext Access 5 Pages 2007
A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials Fulltext Access 5 Pages 2007
Synthesis, in vitro and in vivo cytotoxicity of 6,7-diaryl-2,3,8,8a-tetrahydroindolizin-5(1H)-ones Fulltext Access 5 Pages 2007
Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 1: Substituted pyrazoles Fulltext Access 5 Pages 2007
Design and synthesis of highly potent and selective human peroxisome proliferator-activated receptor α agonists Fulltext Access 5 Pages 2007
Synthesis and structure–activity relationship of a novel, non-hydroxamate series of TNF-α converting enzyme inhibitors Fulltext Access 5 Pages 2007
Heterocyclic α-helix mimetics for targeting protein–protein interactions Fulltext Access 5 Pages 2007
Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain Fulltext Access 5 Pages 2007
CCR5 receptor antagonists: Discovery and SAR of novel 4-hydroxypiperidine derivatives Fulltext Access 5 Pages 2007
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators Fulltext Access 5 Pages 2007
Validate antibacterial mode and find main bioactive components of traditional Chinese medicine Aquilegia oxysepala Fulltext Access 5 Pages 2007
Darpones and water-soluble aminobutoxylated darpone derivatives are distinguished by matrix COMPARE analysis Fulltext Access 5 Pages 2007
Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP) Fulltext Access 5 Pages 2007
Penicillin-bound polyacrylate nanoparticles: Restoring the activity of β-lactam antibiotics against MRSA Fulltext Access 5 Pages 2007
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of an 123I-labeled bicyclic nucleoside analogue (BCNA) as potential SPECT tracer for VZV-tk reporter gene imaging Fulltext Access 5 Pages 2007
Technetium-99m-labeling and synthesis of thymidine analogs: Potential candidates for tumor imaging Fulltext Access 5 Pages 2007
Development of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as orally active human chymase inhibitors Fulltext Access 5 Pages 2007
Annonaceous acetogenin mimics bearing a terminal lactam and their cytotoxicity against cancer cells Fulltext Access 5 Pages 2007
Bis[(para-methoxy)benzyl] phosphonate prodrugs with improved stability and enhanced cell penetration Fulltext Access 5 Pages 2007
Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate) Fulltext Access 5 Pages 2007
Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors Fulltext Access 5 Pages 2007
2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases Fulltext Access 5 Pages 2007
Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors Fulltext Access 5 Pages 2007
Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3 Fulltext Access 5 Pages 2007
Synthesis and antibacterial activity of derivatives of 6-O-allylic acylides Fulltext Access 5 Pages 2007
Design and synthesis of urea and thiourea derivatives and their inhibitory activities on lipopolysaccharide-induced NO production Fulltext Access 5 Pages 2007
Oxidative aromatization of Hantzsch 1,4-dihydropyridines in the presence of mixed-addenda vanadomolybdophosphate heteropolyacid, H6PMo9V3O40 Fulltext Access 5 Pages 2007
Chipping at large, potent human T-cell leukemia virus type 1 protease inhibitors to uncover smaller, equipotent inhibitors Fulltext Access 5 Pages 2007