Synthesis and evaluation of diverse thio avarol derivatives as potential UVB photoprotective candidates Fulltext Access 5 Pages 2007
β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites Fulltext Access 5 Pages 2007
Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon Fulltext Access 5 Pages 2007
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model Fulltext Access 5 Pages 2007
Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors Fulltext Access 5 Pages 2007
Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines Fulltext Access 5 Pages 2007
Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety Fulltext Access 5 Pages 2007
Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors Fulltext Access 5 Pages 2007
Further studies of tyrosine surrogates in opioid receptor peptide ligands Fulltext Access 5 Pages 2007
Epoxygenase eicosanoids: Synthesis of tetrahydrofuran-diol metabolites and their vasoactivity Fulltext Access 5 Pages 2007
4-N-Methyl-N′-(2-dihydroxyboryl-benzyl)amino benzonitrile and its boronate analogue sensing saccharides and fluoride ion Fulltext Access 5 Pages 2007
Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors Fulltext Access 5 Pages 2007
Synthesis and inhibition of cancer cell proliferation of (1,3′)-bis-tetrahydroisoquinolines and piperazine systems Fulltext Access 5 Pages 2007
Structure–activity relationships of some taxoids as multidrug resistance modulator Fulltext Access 5 Pages 2007
Non-covalent complexes between bis-β-carbolines and double-stranded DNA: A study by electrospray ionization FT-ICR mass spectrometry (I) Fulltext Access 5 Pages 2007
Novel 2-aminobenzothiazoles as selective neuronal nitric oxide synthase inhibitors Fulltext Access 5 Pages 2007
Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists Fulltext Access 5 Pages 2007
Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus Fulltext Access 5 Pages 2007
Identification of a novel class of succinyl-nitrile-based Cathepsin S inhibitors Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors Fulltext Access 5 Pages 2007
Synthesis and in vivo antihyperglycemic activity of nature-mimicking furanyl-2-pyranones in STZ-S model Fulltext Access 5 Pages 2007
Synthesis of marine alkaloid: 8,9-Dihydrocoscinamide B and its analogues as Novel class of antileishmanial agents Fulltext Access 5 Pages 2007
Synthesis and biological activity of enantiomeric pairs of 5-vinylthiolactomycin congeners Fulltext Access 5 Pages 2007
Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors Fulltext Access 5 Pages 2007
Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors Fulltext Access 5 Pages 2007
The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure–activity relationships of 2-amino-4-azaindoles Fulltext Access 5 Pages 2007
Synthesis of thiazolone-based sulfonamides as inhibitors of HCV NS5B polymerase Fulltext Access 5 Pages 2007
Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs Fulltext Access 5 Pages 2007
Evaluating scoring functions for docking and designing β-secretase inhibitors Fulltext Access 5 Pages 2007
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists—Increasing selectivity over hERG Fulltext Access 5 Pages 2007
Synthesis and SAR of potent and selective androgen receptor antagonists: 5,6-Dichloro-benzimidazole derivatives Fulltext Access 5 Pages 2007
Dopamine-selective potentiometric responses by new ditopic sensory elements based on a hexahomotrioxacalix[3]arene Fulltext Access 5 Pages 2007
Design and synthesis of phenethyl benzo[1,4]oxazine-3-ones as potent inhibitors of PI3Kinaseγ Fulltext Access 5 Pages 2007
Analogues of the dopamine D2 receptor antagonist L741,626: Binding, function, and SAR Fulltext Access 5 Pages 2007
Benzothiazole benzimidazole (S)-isothiazolidinone derivatives as protein tyrosine phosphatase-1B inhibitors Fulltext Access 5 Pages 2007
Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite Fulltext Access 5 Pages 2007
Novel and potent 3-(2,3-dichlorophenyl)-4-(benzyl)-4H-1,2,4-triazole P2X7 antagonists Fulltext Access 5 Pages 2007
Structure–activity relationship in the 3-iodo-4-phenoxypyridinone (IOPY) series: The nature of the C-3 substituent on anti-HIV activity Fulltext Access 5 Pages 2007
Design, synthesis, and evaluation of efflux substrate–metal chelator conjugates as potential antimicrobial agents Fulltext Access 5 Pages 2007
Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore Fulltext Access 5 Pages 2007
Identification and structure–activity relationships of 1-aryl-3-piperidin-4-yl-urea derivatives as CXCR3 receptor antagonists Fulltext Access 5 Pages 2007
Influence of an additional 2-amino substituent of the 1-aminoethyl pharmacophore group on the potency of rimantadine against influenza virus A Fulltext Access 5 Pages 2007
Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates Fulltext Access 5 Pages 2007
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies Fulltext Access 5 Pages 2007
Novel pyrazolopiperazinone- and pyrrolopiperazinone-based MCH-R1 antagonists Fulltext Access 5 Pages 2007
Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain Fulltext Access 5 Pages 2007
Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase Fulltext Access 5 Pages 2007
Novel heparin/heparan sulfate mimics as inhibitors of HGF/SF-induced MET activation Fulltext Access 5 Pages 2007
A novel flavonoid from Lespedeza virgata (Thunb.) DC.: Structural elucidation and antioxidative activity Fulltext Access 5 Pages 2007
Discovery of 2,4,6-trisubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors Fulltext Access 5 Pages 2007
ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence Fulltext Access 5 Pages 2007
Unique spirocyclopiperazinium salt III: Further investigation of monospirocyclopiperazinium (MSPZ) salts as potential analgesics Fulltext Access 5 Pages 2007
Modification of cap group in δ-lactam-based histone deacetylase (HDAC) inhibitors Fulltext Access 5 Pages 2007
Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency Fulltext Access 5 Pages 2007
New 1,2,3,4-tetrahydropyrrolo[3,4-b]indole derivatives as selective CB2 receptor agonists Fulltext Access 5 Pages 2007
Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: Peptidomimetic replacement of the P2 amino acid by 2-aminoaryl acids and other non-natural amino acids Fulltext Access 5 Pages 2007
Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study Fulltext Access 5 Pages 2007
Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues Fulltext Access 5 Pages 2007
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: Exploration of the 1-position Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of novel cytotoxic azanaphthoquinone annelated pyrrolo oximes Fulltext Access 5 Pages 2007
Synthesis and evaluation of a 99mTc-BAT-phenylbenzothiazole conjugate as a potential in vivo tracer for visualization of amyloid β Fulltext Access 5 Pages 2007
Potent 2′-aminoanilide inhibitors of cFMS as potential anti-inflammatory agents Fulltext Access 5 Pages 2007
Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production Fulltext Access 5 Pages 2007
Synthesis of xanthone derivatives with extended π-systems as α-glucosidase inhibitors: Insight into the probable binding mode Fulltext Access 5 Pages 2007
9-Nitroanthracene derivative as a precursor of anthraquinone for photodynamic therapy Fulltext Access 5 Pages 2007
Antiproliferative and apoptosis inducing properties of pyrano[3,2-c]pyridones accessible by a one-step multicomponent synthesis Fulltext Access 5 Pages 2007
Synthesis and radiopharmacological characterization of [11C]AL-438 as a nonsteroidal ligand for imaging brain glucocorticoid receptors Fulltext Access 5 Pages 2007
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: Discovery of CB2 receptor selective compounds Fulltext Access 5 Pages 2007
Synthesis and preliminary evaluation of mono-[123I]iodohypericin monocarboxylic acid as a necrosis avid imaging agent Fulltext Access 5 Pages 2007
Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists Fulltext Access 5 Pages 2007
Discovery of pyrazine carboxamide CB1 antagonists: The introduction of a hydroxyl group improves the pharmaceutical properties and in vivo efficacy of the series Fulltext Access 5 Pages 2007
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors Fulltext Access 5 Pages 2007
(Phenylpiperidinyl)cyclohexylsulfonamides: Development of α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) Fulltext Access 5 Pages 2007
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 2: Orally bioavailable compounds Fulltext Access 5 Pages 2007
Discovery of novel dialkyl substituted thiophene inhibitors of HCV by in silico screening of the NS5B RdRp Fulltext Access 5 Pages 2007
Synthesis and antibacterial activity of 3-keto-6-O-carbamoyl-11,12-cyclic thiocarbamate erythromycin A derivatives Fulltext Access 5 Pages 2007
The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium Fulltext Access 5 Pages 2007
Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARδ agonists Fulltext Access 5 Pages 2007
7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: Synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase Fulltext Access 5 Pages 2007
C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase Fulltext Access 5 Pages 2007
Novel linear polymers bearing thiosialosides as pendant-type epitopes for influenza neuraminidase inhibitors Fulltext Access 5 Pages 2007
Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: Design, synthesis and biological activity Fulltext Access 5 Pages 2007
Facile one-pot synthesis of thio and selenourea derivatives: A new class of potent urease inhibitors Fulltext Access 5 Pages 2007
3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of substituted 6-alkynyl-4-anilinoquinazoline derivatives as potent EGFR inhibitors Fulltext Access 5 Pages 2007
Highly efficient selective oxidation of alcohols to carbonyl compounds catalyzed by ruthenium (III) meso-tetraphenylporphyrin chloride in the presence of molecular oxygen Fulltext Access 5 Pages 2007
A novel class of Hsp90 inhibitors isolated by structure-based virtual screening Fulltext Access 5 Pages 2007
Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity Fulltext Access 5 Pages 2007