Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) β-glucuronide and β-galactoside for application in selective prodrug chemotherapy Fulltext Access 4 Pages 2007
Synthesis and antimalarial activity of new 1,12-bis(N,N′-acetamidinyl)dodecane derivatives Fulltext Access 4 Pages 2007
Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir Fulltext Access 4 Pages 2007
Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors Fulltext Access 4 Pages 2007
Synthesis of a novel inhibitor against MRSA and VRE: Preparation from zerumbone ring opening material showing histidine-kinase inhibition Fulltext Access 4 Pages 2007
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors Fulltext Access 4 Pages 2007
Amplification of DNA-binding affinities of protoberberine alkaloids by appended polyamines Fulltext Access 4 Pages 2007
MCH-R1 antagonists based on an arginine scaffold: SAR studies on the amino-terminus Fulltext Access 4 Pages 2007
Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase Fulltext Access 4 Pages 2007
2-(2,2,2-Trifluoroethyl)-5,6-dichlorobenzimidazole derivatives as potent androgen receptor antagonists Fulltext Access 4 Pages 2007
5-Propynylamino α-deoxyuridine promotes DNA duplex stabilization of anionic and neutral but not cationic α-oligonucleotides Fulltext Access 4 Pages 2007
Synthesis and antibacterial activities of new quinolone derivatives utilizing 1-azabicyclo[1.1.0]butane Fulltext Access 4 Pages 2007
Kinetic resolution of (±)-1-phenylethanol in [Bmim][PF6] using high activity preparations of lipases Fulltext Access 4 Pages 2007
Synthesis and identification of novel oxa-steroids as progesterone receptor antagonists Fulltext Access 4 Pages 2007
Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives Fulltext Access 4 Pages 2007
Discovery of novel phosphorus-containing steroids as selective glucocorticoid receptor antagonist Fulltext Access 4 Pages 2007
Remarkable immunostimulation effects of hybrid liposomes on human peripheral blood mononuclear cells in vitro Fulltext Access 4 Pages 2007
SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties Fulltext Access 4 Pages 2007
Aminomethyl tetrahydronaphthalene ketopiperazine MCH-R1 antagonists—Increasing selectivity over hERG Fulltext Access 4 Pages 2007
Synthesis and DNA-binding ability of C2R-fluoro substituted DC-81 and its dimers Fulltext Access 4 Pages 2007
Chalcone based aryloxypropanolamines as potential antihyperglycemic agents Fulltext Access 4 Pages 2007
PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil Fulltext Access 4 Pages 2007
Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans. Part 2: Effect of side chain homologation Fulltext Access 4 Pages 2007
Chemico-enzymatic synthesis of a new fluorescent-labeled DNA by PCR with a thymidine nucleotide analogue bearing an acridone derivative Fulltext Access 4 Pages 2007
1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives Fulltext Access 4 Pages 2007
Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors Fulltext Access 4 Pages 2007
Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide Fulltext Access 4 Pages 2007
Natural dibenzoxazepinones from leaves of Carex distachya: Structural elucidation and radical scavenging activity Fulltext Access 4 Pages 2007
Identification of the benzodiazepines as a new class of antileishmanial agent Fulltext Access 4 Pages 2007
Synthesis of 2′-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells Fulltext Access 4 Pages 2007
An efficient synthesis of quinoxaline derivatives from 4-chloro-4-deoxy-α-d-galactose and their cytotoxic activities Fulltext Access 4 Pages 2007
Synthesis of a technetium-99m labeled tricyclic ganciclovir analog for non-invasive reporter gene expression imaging Fulltext Access 4 Pages 2007
N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors Fulltext Access 5 Pages 2007
Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of N-acetyl-β-aryl-1,2-didehydroethylamines as new HIV-1 RT inhibitors in vitro Fulltext Access 5 Pages 2007
Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs Fulltext Access 5 Pages 2007
Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of naproxen Fulltext Access 5 Pages 2007
Himbacine derived thrombin receptor (PAR-1) antagonists: SAR of the pyridine ring Fulltext Access 5 Pages 2007
Novel prodrug approach to photodynamic therapy: Fmoc solid-phase synthesis of a cell permeable peptide incorporating 5-aminolaevulinic acid Fulltext Access 5 Pages 2007
Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors Fulltext Access 5 Pages 2007
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors Fulltext Access 5 Pages 2007
N-(6,7-Dichloro-2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-N-alkylsulfonamides as peripherally restricted N-methyl-d-aspartate receptor antagonists for the treatment of pain Fulltext Access 5 Pages 2007
Anticancer and anti-inflammatory activities of 1,8-naphthyridine-3-carboxamide derivatives Fulltext Access 5 Pages 2007
Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines Fulltext Access 5 Pages 2007
Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase Fulltext Access 5 Pages 2007
1-Arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones as potent and selective α-1a/1d adrenergic receptor ligands Fulltext Access 5 Pages 2007
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel antiproliferative agents: Exploration of core and headpiece structure–activity relationships Fulltext Access 5 Pages 2007
Design and synthesis of BACE1 inhibitors containing a novel norstatine derivative (2R,3R)-3-amino-2-hydroxy-4-(phenylthio)butyric acid Fulltext Access 5 Pages 2007
Immunomodulatory effects of two sapogenins 1 and 2 isolated from Luffa cylindrica in Balb/C mice Fulltext Access 5 Pages 2007
Synthesis and biological evaluation of new taxoids derived from 2-deacetoxytaxinine J Fulltext Access 5 Pages 2007
Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors Fulltext Access 5 Pages 2007
Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part I: Influence of the substitution on the basic nitrogen and the position of the amide on the affinity for D2L, D4.2, and 5-HT2A receptors Fulltext Access 5 Pages 2007
Bile acid-based receptors containing 2,6-bis(acylamino)pyridine for recognition of uracil derivatives Fulltext Access 5 Pages 2007
In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure–activity study Fulltext Access 5 Pages 2007
Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones Fulltext Access 5 Pages 2007
Comparison of N,N′-diarylsquaramides and N,N′-diarylureas as antagonists of the CXCR2 chemokine receptor Fulltext Access 5 Pages 2007
Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands Fulltext Access 5 Pages 2007
Structure–activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors Fulltext Access 5 Pages 2007
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors Fulltext Access 5 Pages 2007
Synthesis and characterization of 8-ethynyl-1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: New potent non-competitive metabotropic glutamate receptor 2/3 antagonists. Part 1 Fulltext Access 5 Pages 2007
Development of CXCR3 antagonists. Part 2: Identification of 2-amino(4-piperidinyl)azoles as potent CXCR3 antagonists Fulltext Access 5 Pages 2007
Large-scale synthesis of a persistent trityl radical for use in biomedical EPR applications and imaging Fulltext Access 5 Pages 2007
Synthesis, anti-HIV activity, and resistance profiles of ribose modified nucleoside phosphonates Fulltext Access 5 Pages 2007
Isolation of quinic acid derivatives and flavonoids from the aerial parts of Lactuca indica L. and their hepatoprotective activity in vitro Fulltext Access 5 Pages 2007
Bis-azaaromatic quaternary ammonium salts as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release: An investigation of binding conformation Fulltext Access 5 Pages 2007
N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors Fulltext Access 5 Pages 2007
N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli Fulltext Access 5 Pages 2007
New ‘chemical probes’ to examine the role of the hFPRL1 (or ALXR) receptor in inflammation Fulltext Access 5 Pages 2007
Rational design of N-alkyl derivatives of 2-amino-2-deoxy-d-glucitol-6P as antifungal agents Fulltext Access 5 Pages 2007
Structure–activity relationship study on the 6-membered heteroaromatic ring system of diphenylpyrazine-type prostacyclin receptor agonists Fulltext Access 5 Pages 2007
2-Aryl-3,3,3-trifluoro-2-hydroxypropionic acids: A new class of protein tyrosine phosphatase 1B inhibitors Fulltext Access 5 Pages 2007
Hit generation and exploration: Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases Fulltext Access 5 Pages 2007
Anti-AIDS agents 73: Structure–activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives Fulltext Access 5 Pages 2007
Redefining the structure–activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4′-phenyl)-phenethyl) analogues of 8-CAC Fulltext Access 5 Pages 2007
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors Fulltext Access 5 Pages 2007
Mechanisms of trovafloxacin hepatotoxicity: Studies of a model cyclopropylamine-containing system Fulltext Access 5 Pages 2007
2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2 Fulltext Access 5 Pages 2007
Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues Fulltext Access 5 Pages 2007
Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues Fulltext Access 5 Pages 2007
Design, synthesis, and evaluation of peptidyl fluorescent probe for Zn2+ in aqueous solution Fulltext Access 5 Pages 2007
HeLa cells apoptosis induced by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane Fulltext Access 5 Pages 2007
The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modifications Fulltext Access 5 Pages 2007
Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation Fulltext Access 5 Pages 2007
Potential synergism and inhibitors to multiple target enzymes of Xuefu Zhuyu Decoction in cardiac disease therapeutics: A computational approach Fulltext Access 5 Pages 2007
Identification of novel glycine sulfonamide antagonists for the EP1 receptor Fulltext Access 5 Pages 2007
1,3-Diaminopropan-2-ol Sulfonamides as potent and selective inhibitors of the glycine transporter type 1 Fulltext Access 5 Pages 2007
New thiopyrazolo[3,4-d]pyrimidine derivatives as anti-mycobacterial agents Fulltext Access 5 Pages 2007